Game Time: 8:10 pm ET, Wednesday, May 25, 2022
Venue: Guaranteed Rate Field, Chicago, IL
Where to Watch: MLB Network
Opening Odds at USA Sportsbooks
DraftKings: Moneyline odds: Red Sox +150, White Sox -170; Over/Under: 8 runs
Bet365: Moneyline odds: Red Sox +150, White Sox -170; Over/Under: 8 runs
BetMGM: Moneyline odds: Red Sox +150, White Sox -170; Over/Under: 8 runs
Boston Red Sox: 19-22 (4th place, AL East)
Chicago White Sox: 21-20 (2nd place, AL Central)
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Boston Red Sox vs Chicago White Sox Preview and Analysis
Boston Red Sox: 8-2 last 10
Chicago White Sox: 6-4 last 10
Boston Red Sox Analysis
The Red Sox are coming into this game with a 19-22 record overall and they are 9-12 in their road games this season where they will be in this game. They have won 6 of their last 7 games and are coming into this one on a 5 game winning streak. They just won their 4-game series against the Seattle Mariners completing the sweep 4-0, had Monday off as a rest day, and they are playing the 2nd game of a 3-game series with the White Sox on Wednesday. This will be the 2nd game of the series on Wednesday with the series opener still to be played on Tuesday. Nick Pivetta is the starting pitcher for them on Tuesday while Rich Hill is on the mound for them here on Wednesday. He is 1-1 with a 3.90 ERA this season. His team won 3 of their last 4 games this season with him starting. In his last start, he allowed 4 ER, 1 HR, and 1 BB with 2 Ks on 6 hits in 2 IP against the Seattle Mariners. They scored 33 runs in their last series averaging just over 8 runs scored per game in that span and they allowed 18 runs against them averaging just over 4 runs allowed per game.
Chicago White Sox Analysis
The White Sox are coming into this game with a 21-20 record overall and they are 12-10 in their home games this season where they will be in this game. They have won 3 of their last 4 games and are coming into this one on a 2 game winning streak. They just won their 3-game series against the New York Yankees 2-1, had Monday off as a rest day, and they are playing the 2nd game of a 3-game series with the Red Sox on Wednesday. This will be the 2nd game of the series on Wednesday with the series opener still to be played on Tuesday. Dylan Cease is the starting pitcher for them on Tuesday while Lucas Giolito will be on the mound for them here on Wednesday. He is 2-1 with a 2.84 ERA this season. His team won 2 of their last 3 games this season with him as a starter. In his last start, he allowed 2 earned runs, 1 homer, and 2 BB with 7 strikeouts on 7 hits in 5 innings played against the Kansas City Royals. They scored 13 runs in their last series averaging just over 4 runs scored per game in that span and they allowed 8 runs against them averaging just under 3 runs allowed per game.
Red Sox vs White Sox Prediction
The White Sox are coming into this game as a big favorite with the current betting odds. The White Sox have been starting to play much better in their recent games. They just won their last series against the Yankees and they have been both hitting the ball and pitching much better in their recent games. They are going up against a Red Sox team that has also been heating up in their recent games. The Red Sox have Hill on the mound here though and he has not been awful this season but he has not been great either. The White Sox have Giolitto starting here and he has been having a great season as he is one of the more reliable pitchers on the pitching staff for the White Sox. The White Sox are also at home here and will have a lot of confidence after the series they just put up against the Yankees. The best bet here is on the White Sox to win this game.
Red Sox White Sox Prediction: Our MLB Pick for Wednesday, May 25, 2022 (8:10 pm ET start time) is White Sox 6 Red Sox 3.
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MLB Betting Trends
Boston Red Sox: 41-45 (+9.5 Units) ML as a road underdog of +100 or higher. 94-78 (+10.4 Units) ML against right-handed starters. 12-5 UNDER as an underdog of +100 or higher.
Chicago White Sox: 44-27 (-7.2 Units) ML as a home favorite of -150 or more. 79-71 (-15.8 Units) ML when the total is 7 to 8.5. 23-16 UNDER in all games.
Boston Red Sox: A. Verdugo (RF) Prob Tues - Illness. J. Taylor (RP) Out indefinitely - Back. C. Sale (SP) Mid June - Ribs.
Chicago White Sox: L. Lynn (SP) Mid June - Knee. E. Jimenez (LF) Late June - Hamstring. G. Crochet (RP) out for season - Elbow.
"I got back to the basics for me. Sticking the heaters down and away, but making sure I was getting them down in the zone. ... I felt like I did a better job of really commanding the zone." - Nathan Eovaldi after their win against the Mariners on Sunday.
"He deserves the recognition and he deserves the respect. If somebody disrespects him, he should get upset. I know I would." - Tony La Russa on Tim Anderson after his team’s win against the Yankees on Sunday in game 2.
Boston Red Sox
Enrique Hernandez (R) CF
Rafael Devers (L) 3B
J.D. Martinez (R) DH
Xander Bogaerts (R) SS
Alex Verdugo (L) LF
Trevor Story (R) 2B
Franchy Cordero (L) 1B
Christian Vazquez (R) C
Jackie Bradley Jr. (L) RF
Chicago White Sox
Tim Anderson (R) SS
Yoan Moncada (S) 3B
AJ Pollock (R) LF
Jose Abreu (R) 1B
Yasmani Grandal (S) C
Gavin Sheets (L) DH
Leury Garcia (S) 2B
Andrew Vaughn (R) RF
Adam Engel (R) CF
Boston Red Sox
Batting Average: Jaylin Davis (.500)
Hits: Rafael Devers (57)
Home Runs: Rafael Devers (9)
RBI: Trevor Story (29)
Stolen Bases: Trevor Story (5)
Wins: Michael Wacha (3)
Saves: Hansel Robles (2)
ERA: John Schreiber (0.00)
Chicago White Sox
Batting Average: Tim Anderson (.359)
Hits: Tim Anderson (52)
Home Runs: Luis Robert (6)
RBI: Tim Anderson (18)
Stolen Bases: Tim Anderson (7)
Wins: Reynaldo Lopez (4)
Saves: Liam Hendriks (13)
ERA: Johnny Cueto (0.00)
Boston Red Sox: Alex Cora (4th season)
Chicago White Sox: Tony La Russa (2nd season)