Boston Celtics vs Philadelphia 76ers Prediction, Preview and Odds - 10/31/2025

Game Time: 7:00 pm ET, Friday, October 31, 2025

Venue:  Xfinity Mobile Arena, Philadelphia, PA 

Where to Watch:  Prime Video

DraftKings:  Point Spread:  Celtics +3.5, 76ers -3.5; Over/Under:  232.5 points

Bet365:  Point Spread:  Celtics +3.5, 76ers -3.5; Over/Under:  232.5 points

BetMGM:  Point Spread:  Celtics +3.5, 76ers -3.5; Over/Under:  232.5 points

Boston Celtics:  2-3 (3rd place, Atlantic Division)

Philadelphia 76ers:  4-0 (1st place, Atlantic Division)

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Boston Celtics:  2-3 last 5

Philadelphia 76ers:  4-0 last 4

The Celtics are entering this game with a 2-3 record overall this season and they are 1-2 in their road games this season where they will be in this game. They are entering this game on a 2 game winning streak with wins coming against the New Orleans Pelicans and the Cleveland Cavaliers. Jaylen Brown led the team in points in that game with 30 while Sam Hauser was next on the team with 21 points. Payton Pritchard led the team in assists in that game with 10 while Josh Minott led the team in rebounds with 14. They were 44.2% from the field, 36.8% from 3-point range, and 83.3% from the free throw line with their shots in that game. Their offense is averaging 114.2 PPG and their defense is allowing their opponents to average 107.2 PPG against them. The Celtics have an ATS record of 2-3 this season and their O/U record is 2-3.

The 76ers are entering this game with a 4-0 record overall this season and they are 2-0 in their home games this season where they will be in this game. They are entering this game on a 4 game winning streak with wins coming against the Boston Celtics, the Charlotte Hornets, the Orlando Magic, and the Washington Wizards. Tyrese Maxey led the team in points in that game with 39 while Joel Embiid was next on the team with 25 points. Tyrese Maxey led the team in assists in that game with 10 while Kelly Oubre Jr. led the team in rebounds with 11. They were 45% from the field, 40.5% from 3-point range, and 86.5% from the free throw line with their shots in that game. Their offense is averaging 129.3 PPG and their defense is allowing their opponents to average 123.8 PPG against them. The 76ers have an ATS record of 3-1 this season and their O/U record is 4-0.

The current betting odds have the 76ers listed as a 3.5 point favorite in this game according to Draftkings Sportsbook. The 76ers have looked great in their games this season with their 4-0 record overall which has them right at the top of the East with one of the best records in the NBA to start the season. They have also looked good on their home court with their 2-0 home record this year. Meanwhile, the Celtics haven't looked great in their games this season with their 2-3 record overall which has them right near the bottom of the East. They haven't been a great road team so far with their 1-2 road record. They had a terrible start to the season with 3 losses in a row, but they have looked a lot better in their games lately. They have won 2 games in a row now and have some momentum, but their only road win was also against the winless Pelicans. They are off a home win over the Cavaliers in their last one, but they aren't in a great situation as a team this year with Tatum out, and they did lose a lot of talent in the off-season too. The 76ers had a terrible season last year, but they are looking to turn things around this year with a hot start and they already have a win over the Celtics in Boston to start the season. The 76ers have been rolling with Embiid back in the lineup healthy and their new draft pick Edgecombe making some noise too. The 76ers are going to bring their best effort for the struggling Celtics at home, especially with this being the 1st game of the NBA Cup. The best way to place a bet here is on the 76ers to cover the spread in this game. 

Celtics 76ers Prediction:  Our NBA Pick for Friday, October 31, 2025 (7:00 pm ET start time) is 76ers 118 Celtics 112.

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Boston Celtics: 22-11 ATS revenging a same season loss vs opponent. 11-5 ATS revenging a straight up loss vs opponent as a home favorite. 9-3 UNDER as a road underdog of 6 points or less. 13-6 UNDER revenging a home loss vs opponent.

Philadelphia 76ers: 9-18 ATS as a home favorite of 6 points or less. 6-12 ATS at home when the line is +3 to -3. 13-20 ATS when playing against a marginal losing team (Win Pct. 40% to 49%). 21-12 UNDER when playing against a marginal losing team (Win Pct. 40% to 49%).

Boston Celtics:  J. Tatum (PF) Out - Achilles.

Philadelphia 76ers:  D. Barlow (PF) Day To Day - Elbow. P. George (PF) Day To Day - Knee. J. McCain (SG) Out - Thumb.

"You have to make the choice every day when you wake up in the morning that you're going to rebound on both ends of the floor." - Joe Mazzulla after his team’s win against the Cavaliers in their game on Wednesday.

"He looks pretty good. I mean, again, you're right on all the stuff--it was pretty minimal today, and it's kind of his first time joining us. Really wasn't any contact or anything today, and I've said this several times, but he's worked extremely hard, right? On a number of fronts, to get back and play. So I think from a conditioning standpoint, I think he's going to be in a good place, but it’s never like actually playing in a game." - Nick Nurse on the injury to Jared McCain.

PG Derrick White

SG Payton Pritchard

SF Jaylen Brown

PF Josh Minott

C Neemias Queta

PG Tyrese Maxey

SG VJ Edgecombe

SF Kelly Oubre Jr.

PF Trendon Watford

C Joel Embiid

PPG: Jaylen Brown (26.8)

APG: Payton Pritchard (6)

Reb/G: Neemias Queta (9)

PPG: Tyrese Maxey (37.5)

APG: Tyrese Maxey (8.3)

Reb/G: Andre Drummond (7.5)

Coaches:

Boston Celtics: Joe Mazzulla (4th season)

Philadelphia 76ers: Nick Nurse (3rd season)