Boston Bruins vs Buffalo Sabres Prediction, Preview and Odds - 03/25/2026

Game Time: 7:30 pm ET, Wednesday, March 25, 2026

Venue:  KeyBank Center, Buffalo, NY

Where to Watch:  TNT, HBO Max, truTV

DraftKings:  Moneyline:  Bruins +150, Sabres -180; Over/Under:  6.5 goals

Bet365:  Moneyline:  Bruins +150, Sabres -180; Over/Under:  6.5 goals

BetMGM:  Moneyline:  Bruins +150, Sabres -180; Over/Under:  6.5 goals

Boston Bruins:  39-23-8 (4th place, Atlantic Division)

Buffalo Sabres:  44-20-7 (1st place, Atlantic Division)

Do not miss out on our expert handicapper analysis! William Burns is on a HOT STREAK in the NHL on an 18-2 NHL RUN for +$16,290 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Boston Bruins:  5-2-3 last 10

Buffalo Sabres:  8-1-1 last 10

The Bruins are entering this game with 86 points, a 39-23-8 record overall, and they are 13-14-7 in their road games this season where they will be in this game. They are entering this game off a win against the Detroit Red Wings in their last game, winning that one on the road 4-2, but this is also the 2nd game of a back-to-back for them with their game against the Toronto Maple Leafs still to be played on Tuesday night. In their game against the Red Wings, David Pastrnak, Elias Lindholm, Marat Khusnutdinov, and Nikita Zadorov each scored 1 goal for them in that one. Morgan Geekie led the team in assists with 3 while Elias Lindholm and Viktor Arvidsson each led the team in shots on net in that game with 4. Jeremy Swayman was the starting goalie in that game and he allowed 2 goals on 43 shots with 41 saves and a .953 save percentage. Their offense has scored 234 goals this season averaging 3.3 goals per game and their defense has allowed their opponents to score 217 goals against them allowing 3.1 goals per game.

The Sabres are entering this game with 95 points, a 44-20-7 record overall, and they are 22-9-3 in their home games this season where they will be in this game. They are entering this game off a loss against the Anaheim Ducks in their last game, losing that one on the road 6-5 in overtime. Owen Power, Zach Benson, Alex Tuch, Jack Quinn, and Josh Doan each scored 1 goal for them in that one. Rasmus Dahlin led the team in assists with 2 while Rasmus Dahlin led the team in shots on net in that game with 4. Alex Lyon was the starting goalie in that game and he allowed 6 goals on 33 shots with 27 saves and a .818 sv percentage. Their offense has scored 251 goals this season averaging 3.5 goals per game and their defense has allowed their opponents to score 207 goals against them allowing 2.9 goals per game.

The current betting odds have the Sabres listed as a favorite in this game according to Draftkings Sportsbook. The Sabres have looked great in their games this season with their 44-20-7 record overall which has them right at the top of their division in the East with one of the best records in the entire NHL. They have looked great on home ice too with their 22-9-3 home record this season. Meanwhile, the Bruins have looked good in their games this season with their 39-23-8 record overall which has them in the top half of their division in the East. They have been a terrible road team though with their 13-14-7 road record this year. The Bruins are in the first Wild Card spot at the moment, but it is a really tight race and they need every point they can get. They are off a 4-2 win over the Red Wings in their last one and that was a huge win for the Wild Card race, but they really haven't looked that great lately. They are 5-2-3 in their last 10 games and they aren't in a good situation here either, playing this game on a back-to-back with a game against the Maple Leafs the night before. The Sabres are off a 6-5 loss to the Ducks in their last one, but they have been rolling lately and will be looking to bounce back from that tight loss. They are 8-1-1 in their last 10 games and that was a really back and forth game that they lost, making a big comeback to almost win the game. The Sabres are also going to be rested here since they aren't on a back-to-back and they have looked their best at home this season, so look for them to take advantage of the road troubles that the Bruins have had all year. The best way to place a bet here is on the Sabres to win this game and on the puckline. 

Bruins Sabres Prediction:  Our NHL Pick for Wednesday, March 25, 2026 (7:30 pm ET start time) is Sabres 4 Bruins 1.

Don't miss our champion handicappers free picks and expert hockey picks today. And if you enjoyed this Boston Bruins Buffalo Sabres prediction, be sure to drop by every day for our weekly NHL predictions and previews.

Boston Bruins: 125-122 (-13.1 units) on the moneyline in all games. 69-76 (-8.2 units) on the moneyline against explosive offensive teams - scoring 3+ goals/game. 115-117 (-15.4 units) on the moneyline against mistake free teams - opponents average 4 power plays/game or less. 25-18 OVER as a road underdog of +100 to +150.

Buffalo Sabres: 55-35 (+9.3 units) on the moneyline as a favorite of -200 or less. 33-30 (+9.3 units) on the moneyline when playing against a marginal winning team (Win Pct. 51% to 60%). 70-72 (+14.3 units) on the moneyline against explosive offensive teams - scoring 3+ goals/game. 15-8 OVER after allowing 6 goals or more.

Boston Bruins:  None.

Buffalo Sabres:  T. Pearson (LW) Day To Day - Lower-Body. J. Kulich (C) Out For Season - Ear. J. Greenway (LW) Out - Abdomen. C. Timmins (D) Out - Leg. J. Danforth (RW) Out - Lower Body.

“That was the best I’ve seen (Swayman) play since I’ve been around. He was unbelievable -- he won the game for us.” - Marco Sturm after his team’s win against the Red Wings in their game on Saturday.

"Lyon made some huge saves when we needed them. We were fortunate to get a point out of that one. Obviously, it would have been nice to get another one, but getting points on all four games of this road trip is not an easy thing to do." - Tage Thompson after their loss against the Ducks in their game on Sunday.

LW Marat Khusnutdinov

C Fraser Minten

RW David Pastrnak

LD Jonathan Aspirot

RD Charlie McAvoy

G Jeremy Swayman

LW Peyton Krebs

C Tage Thompson

RW Alex Tuch

LD Rasmus Dahlin

RD Mattias Samuelsson

G Ukko-Pekka Luukkonen

Points: David Pastrnak (86)

Goals: Morgan Geekie (34)

Assists: David Pastrnak (58)

GAA: Jeremy Swayman (2.71)

Points: Tage Thompson (72)

Goals: Tage Thompson (36)

Assists: Rasmus Dahlin (50)

GAA: Ukko-Pekka Luukkonen (2.54)

Coaches:

Boston Bruins: Marco Sturm (1st season)

Buffalo Sabres: Lindy Ruff (2nd season)