Baltimore Orioles vs Boston Red Sox Prediction, Preview and Odds - 07/22/2026

Game Time: 7:10 pm ET, Wednesday, July 22, 2026

Venue:  Fenway Park, Boston, MA

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Orioles +135, Red Sox -163; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Orioles +135, Red Sox -165; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Orioles +135, Red Sox -165; Over/Under:  8.5 runs

Baltimore Orioles:  49-52 (4th place, AL East)

Boston Red Sox:  51-48 (3rd place, AL East)

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Baltimore Orioles:  7-3 last 10

Boston Red Sox:  10-0 last 10

The Orioles are entering this series off a win and completed the sweep in their 3-game series against the Houston Astros 3-0 in their last series. They enter this game with a 49-52 record overall and have a road record of 21-27. This is the series finale of a 3-game series with the Red Sox on Wednesday with the 2nd game still to be played on Tuesday. The Orioles lost the series opener on Monday. Their offense ranks 16th in the MLB with a .719 OPS. Kyle Bradish is their starting pitcher on Tuesday while Dean Kremer is making his start in this game on Wednesday. He is 1-2 with a 4.15 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 0 HR, and 3 BB with 5 SO on 4 hits through 4 IP against the Houston Astros.

The Red Sox are entering this series off a win and completed the sweep in their 4-game series against the Tampa Bay Rays 4-0 in their last series. They enter this game with a 51-48 record overall and have a home record of 22-27. This is the 3rd game of a 3-game series with the Orioles on Wednesday with the 2nd game of this series still to be played on Tuesday. The Red Sox won the 1st game of this series on Monday. Their offense ranks 20th in the MLB with a .709 OPS. Rookie pitcher Eduardo Rivera is their starting pitcher on Tuesday while rookie pitcher Jake Bennett is making his start in this game on Wednesday. He is 5-3 with a 2.35 ERA this season. His team won their last 4 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 1 walk with 3 strikeouts on 1 hit through 6 innings pitched against the Tampa Bay Rays.

The current betting odds have the Red Sox listed as a favorite in this game according to Draftkings Sportsbook. The Red Sox have looked good in their games this season with their 51-48 record overall which has them right in the middle of the AL East. They haven't looked great in their own ballpark though with their 22-27 home record this season. Meanwhile, the Orioles haven't looked great in their games this season with their 49-52 record overall which has them right near the bottom of the AL East. They haven't been a great road team either with their 21-27 road record this year. The Orioles have been rolling lately as they are 7-3 in their last 10 games, but they still haven't been the hotter team in this series. The Red Sox are 10-0 in their last 10 games and have a ton of momentum on their side with 13 wins in a row entering this series. Their offense has looked a lot better lately too and they are going to have the better pitching matchup in this one. Bennett is on the mound for the Red Sox in this one and he has looked great this season. He is 5-3 with a 2.35 ERA and he has been having a great rookie year. He is coming off another great start in which he gave up no runs which has been a common theme for him and the team has had a ton of success lately too, winning 4 games in a row now with him starting. The Orioles are going with Kremer in this one and he hasn't looked great this season. He is 1-2 with a 4.15 ERA and he has been giving up quite a few runs all year. The team has had more success with him lately, winning 2 of their last 3 games with him starting, and he only gave up 2 earned runs in his last start too, but that hasn't been a common theme for him this year and this Red Sox offense has been really hot lately. Look for the Red Sox to take advantage of this pitching matchup and continue rolling at home on this big streak. The best way to place a bet here is on the Red Sox to win this game. 

Orioles Red Sox Prediction:  Our MLB Pick for Wednesday, July 22, 2026 (7:10 pm ET start time) is Red Sox 4 Orioles 2.

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Baltimore Orioles: 215-212 (-21.4 units) on the moneyline in all games. 57-64 (-10.4 units) on the moneyline against left-handed starters. 100-114 (-11.6 units) on the moneyline when playing against a team with a winning record. 66-49 UNDER against left-handed starters.

Boston Red Sox: 72-66 (+6.9 units) on the moneyline against division opponents. 147-122 (+9.8 units) on the moneyline vs. an AL team with an on base percentage .330 or worse. 152-128 (+21.4 units) on the moneyline vs. a team with a good bullpen whose WHIP is 1.350 or better. 23-15 UNDER when playing against a team with a losing record.

Baltimore Orioles:  S. Basallo (C) Day To Day - Shoulder. A. Rutschman (C) Ten Day IL - Wrist. B. Alexander (3B) Ten Day IL - Hand. K. Akin (RP) Sixty Day IL - Elbow. R. Helsley (RP) Sixty Day IL - Elbow. C. Bassitt (SP) Sixty Day IL - Back. R. Mountcastle (1B) Sixty Day IL - Foot. Z. Eflin (SP) Sixty Day IL - Elbow. J. Westburg (3B) Sixty Day IL - UCL. F. Bautista (RP) Sixty Day IL - Shoulder. C. Selby (SP) Sixty Day IL - Shoulder.

Boston Red Sox:  R. Suarez (SP) Fifteen Day IL - Groin. C. Early (SP) Fifteen Day IL - Elbow. R. Anthony (LF) Sixty Day IL - Wrist. M. Mayer (2B) Ten Day IL - Forearm. I. Kiner-Falefa (2B) Ten Day IL - Forearm. G. Crochet (SP) Sixty Day IL - Shoulder. T. Story (SS) Sixty Day IL - Abdomen. K. Crawford (SP) Sixty Day IL - Wrist. T. Casas (1B) Sixty Day IL - Knee. J. Oviedo (SP) Sixty Day IL - Elbow. T. Houck (SP) Sixty Day IL - Elbow.

“It was one of those games where whoever was left upright, standing, was going to win. I’m proud of our guys, the way they fought.” - Craig Albernaz after his team’s loss against the Red Sox in their game on Monday. 

“It’s similar to Abreu the other day. The dugout's alive, and you still feel it in there. Even each time that we lost the lead, we did a good job in the bullpen. Even when they lost the lead, they’d keep it to within a run to give us a shot. But they keep coming in feeling like if it stays there, we're gonna have a chance to win the game. They're playing good team baseball right now.” - Chad Tracy after his team’s win against the Orioles in their game on Monday. 

Taylor Ward (R) LF

Pete Alonso (R) 1B

Gunnar Henderson (L) SS

Tyler O'Neill (R) RF

Coby Mayo (R) DH

Leody Taveras (S) CF

Jeremiah Jackson (R) 2B

Christian Encarnacion-Strand (R) 3B

Sam Huff (R) C

Anthony Seigler (S) 2B

Ceddanne Rafaela (R) CF

Wilyer Abreu (L) RF

Willson Contreras (R) 1B

Masataka Yoshida (L) DH

Caleb Durbin (R) 3B

Jarren Duran (L) LF

Connor Wong (R) C

Tsung-Che Cheng (L) SS

Batting Average:  Chadwick Tromp (.667)

Hits:  Gunnar Henderson (93)

Home Runs:  Pete Alonso (21)

RBI:  Pete Alonso (66)

Stolen Bases:  Leody Taveras (10)

Wins:  Brandon Young (8)

Saves:  Ryan Helsley (8)

ERA:  Jose Espada (0.00)

Batting Average:  Jahmai Jones (.400)

Hits:  Ceddanne Rafaela (102)

Home Runs:  Willson Contreras (22)

RBI:  Willson Contreras (66)

Stolen Bases:  Jarren Duran (14)

Wins:  Sonny Gray (12)

Saves:  Aroldis Chapman (22)

ERA:  Aroldis Chapman (1.99)

Managers:

Baltimore Orioles: Craig Albernaz (1st season)

Boston Red Sox: Chad Tracy (Interim)