Baltimore Orioles vs Boston Red Sox Prediction, Preview and Odds - 07/21/2026

Game Time: 7:10 pm ET, Tuesday, July 21, 2026

Venue:  Fenway Park, Boston, MA

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Orioles +113, Red Sox -136; Over/Under:  8 runs

Bet365:  Moneyline odds:  Orioles +115, Red Sox -135; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Orioles +115, Red Sox -135; Over/Under:  8 runs

Baltimore Orioles:  49-51 (4th place, AL East)

Boston Red Sox:  50-48 (3rd place, AL East)

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Baltimore Orioles:  7-3 last 10

Boston Red Sox:  10-0 last 10

The Orioles are entering this series off a win and completed the sweep in their 3-game series against the Houston Astros 3-0 in their last series. They enter this game with a 49-51 record overall and have a road record of 21-26. This is the 2nd game of a 3-game series with the Red Sox on Tuesday with the series opener still to be played on Monday. Their offense ranks 17th in the MLB with a .717 OPS. Shane Baz is their starting pitcher on Monday while Kyle Bradish is making his start in this game on Tuesday. He is 6-9 with a 3.61 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 1 ER, 0 HR, and 2 BB with 5 SO on 2 hits through 6.2 IP against the Kansas City Royals.

The Red Sox are entering this series off a win and completed the sweep in their 4-game series against the Tampa Bay Rays 4-0 in their last series. They enter this game with a 50-48 record overall and have a home record of 21-27. This is the 2nd game of a 3-game series with the Orioles on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 21st in the MLB with a .708 OPS. Payton Tolle is their starting pitcher on Monday while Ranger Suárez is making his start in this game on Tuesday. He is 4-3 with a 3.15 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 3 earned runs, 0 homers, and 0 walks with 5 strikeouts on 6 hits through 2.2 innings pitched against the Los Angeles Angels.

The current betting odds have the Red Sox listed as a favorite in this game according to Draftkings Sportsbook. The Red Sox have looked good in their games this season with their 50-48 record overall which has them right in the middle of the AL East. They haven't looked great in their own ballpark though with their 21-27 home record this season. Meanwhile, the Orioles haven't looked great in their games this season with their 49-51 record overall which has them right near the bottom of the AL East. They haven't been a great road team either with their 21-26 road record this year. The Orioles have been rolling lately though, now 7-3 in their last 10 games, and they just swept the Astros coming out of the All-Star break. As hot as they have been lately, the Red Sox have still been the hotter team, now 10-0 in their last 10 games. The Red Sox have been rolling lately, playing themselves back into the playoff race in the AL, and they have had some great pitching all season. They are starting to get healthier now too with some starters coming back and their bullpen hasn't been giving up many runs on this long win streak. The Orioles are going with Bradish in this one and he hasn't looked great this season. He is 6-9 with a 3.61 ERA and hasn't been giving up many runs lately, but the team hasn't had a ton of success with him this year. They have lost 2 of their last 3 games with him starting too and even though he only gave up 1 earned run in his last start, he will have more trouble here with the Red Sox getting hot offensively. Look for the Red Sox to continue rolling at home with the better pitching staff in this one. The best way to place a bet here is on the Red Sox to win this game. 

Orioles Red Sox Prediction:  Our MLB Pick for Tuesday, July 21, 2026 (7:10 pm ET start time) is Red Sox 5 Orioles 3.

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Baltimore Orioles: 215-211 (-20.4 units) on the moneyline in all games. 57-63 (-9.4 units) on the moneyline against left-handed starters. 100-113 (-10.6 units) on the moneyline when playing against a team with a winning record. 66-48 UNDER against left-handed starters.

Boston Red Sox: 71-66 (+5.9 units) on the moneyline against division opponents. 146-122 (+8.8 units) on the moneyline vs. an AL team with an on base percentage .330 or worse. 151-128 (+20.4 units) on the moneyline vs. a team with a good bullpen whose WHIP is 1.350 or better. 23-14 UNDER when playing against a team with a losing record.

Baltimore Orioles:  S. Basallo (C) Day To Day - Shoulder. B. Alexander (3B) Ten Day IL - Hand. K. Akin (RP) Sixty Day IL - Elbow. R. Helsley (RP) Sixty Day IL - Elbow. C. Bassitt (SP) Sixty Day IL - Back. R. Mountcastle (1B) Sixty Day IL - Foot. Z. Eflin (SP) Sixty Day IL - Elbow. J. Westburg (3B) Sixty Day IL - UCL. F. Bautista (RP) Sixty Day IL - Shoulder. C. Selby (SP) Sixty Day IL - Shoulder.

Boston Red Sox:  R. Suarez (SP) Fifteen Day IL - Groin. C. Early (SP) Fifteen Day IL - Elbow. R. Anthony (LF) Sixty Day IL - Wrist. M. Mayer (2B) Ten Day IL - Forearm. I. Kiner-Falefa (2B) Ten Day IL - Forearm. G. Crochet (SP) Sixty Day IL - Shoulder. T. Story (SS) Sixty Day IL - Abdomen. K. Crawford (SP) Sixty Day IL - Wrist. T. Casas (1B) Sixty Day IL - Knee. J. Oviedo (SP) Sixty Day IL - Elbow. T. Houck (SP) Sixty Day IL - Elbow.

“B.Y. was outstanding today. Our pitching staff as a whole had one walk. B.Y. was real efficient, attacking the strike zone [and] had all of his pitches working. It was a really fun outing to watch him do his thing.” - Craig Albernaz after his team’s win against the Astros in their game on Sunday. 

“It’s pretty incredible and it's a fun ride, and we want to keep it going.” - Chad Tracy on his team’s win streak after their win against the Rays in their game on Sunday. 

Gunnar Henderson (L) SS

Taylor Ward (R) DH

Dylan Beavers (L) LF

Pete Alonso (R) 1B

Samuel Basallo (L) C

Leody Taveras (S) RF

Colton Cowser (L) CF

Coby Mayo (R) 3B

Jackson Holliday (L) 2B

Jahmai Jones (R) DH

Ceddanne Rafaela (R) CF

Wilyer Abreu (L) RF

Willson Contreras (R) 1B

Caleb Durbin (R) 3B

Romy Gonzalez (R) 2B

Andruw Monasterio (R) SS

Jarren Duran (L) LF

Connor Wong (R) C

Batting Average:  Chadwick Tromp (.667)

Hits:  Taylor Ward (92)

Home Runs:  Pete Alonso (21)

RBI:  Pete Alonso (66)

Stolen Bases:  Leody Taveras (10)

Wins:  Brandon Young (8)

Saves:  Ryan Helsley (8)

ERA:  Jose Espada (0.00)

Batting Average:  Jahmai Jones (.400)

Hits:  Ceddanne Rafaela (101)

Home Runs:  Willson Contreras (22)

RBI:  Willson Contreras (64)

Stolen Bases:  Jarren Duran (14)

Wins:  Sonny Gray (12)

Saves:  Aroldis Chapman (21)

ERA:  Aroldis Chapman (2.05)

Managers:

Baltimore Orioles: Craig Albernaz (1st season)

Boston Red Sox: Chad Tracy (Interim)