Atlanta Braves vs Milwaukee Brewers Prediction, Preview and Odds - 08/21/2026

Game Time: 4:10 pm ET, Friday, August 21, 2026

Venue:  American Family Field, Milwaukee, WI

Where to Watch:  ESPN Unlimited, MLB TV

DraftKings:  Moneyline odds:  Braves +123, Brewers -149; Over/Under:  6.5 runs

Bet365:  Moneyline odds:  Braves +125, Brewers -150; Over/Under:  6.5 runs

BetMGM:  Moneyline odds:  Braves +125, Brewers -150; Over/Under:  6.5 runs

Atlanta Braves:  74-53 (1st place, NL East)

Milwaukee Brewers:  78-49 (1st place, NL Central)

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Atlanta Braves:  4-6 last 10

Milwaukee Brewers:  5-5 last 10

The Braves are entering this series off a win and won their 1-off game against the Chicago White Sox on Thursday. They enter this game with a 74-53 record overall and have a road record of 32-30. This is the series opener of a 3-game series with the Brewers on Friday. Their offense ranks 14th in the MLB with a .724 OPS. Grant Holmes was their starting pitcher on Thursday while Chris Sale is making his start in this game on Friday. He is 12-8 with a 2.16 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 1 ER, 0 HR, and 0 BB with 9 SO on 5 hits through 6 IP against the Arizona Diamondbacks.

The Brewers are entering this series off a win and won their 3-game series against the Seattle Mariners 2-1 in their last series. They enter this game with a 78-49 record overall and have a home record of 42-23. This is the 1st game of a 3-game series with the Braves on Friday. Their offense ranks 7th in the MLB with a .734 OPS. Robert Gasser was their starting pitcher on Thursday while Jacob Misiorowski is making his start in this game on Friday. He is 12-5 with a 1.75 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 1 walk with 6 strikeouts on 5 hits through 6 innings pitched against the Los Angeles Dodgers.

The current betting odds have the Brewers listed as a favorite in this game according to Draftkings Sportsbook. The Brewers have looked great in their games this season with their 78-49 record overall which has them right at the top of the NL Central with the best record in MLB. They have looked great in their own ballpark too with their 42-23 home record this season. Meanwhile, the Braves have looked great in their games this season with their 74-53 record overall which has them right at the top of the NL East with one of the best records in MLB. They have been a good road team too with their 32-30 road record this year. The Braves haven't looked nearly as good in their road games this season though and they haven't looked great lately either. They are 4-6 in their last 10 games and before winning that single game against the White Sox, they did get swept by the Twins in their last series. The Brewers are only 5-5 in their last 10 games, but they have been getting hot again with a series win over the Mariners and their offense has been putting up a ton of runs lately too. The Brewers are going with Misiorowski in this one and he has looked great this season. He is 12-5 with a 1.75 ERA and he has been one of the best starters in the league this season. He is coming off another great start giving up 1 earned run against the Dodgers which has been a common theme for him all year and the team has been having a ton of success with him lately, winning 2 games in a row now with him starting. The Braves are going with Sale in this one and he has looked great this season too. He is 12-8 with a 2.16 ERA and he has been their ace this year. He only gave up 1 earned run in his last start which has been a common theme for him, but the team has lost 2 games in a row now with him starting. The Braves do have a good offense themselves, but they haven't been putting up a lot of runs lately, so with 2 great starters here, the Brewers should have the edge with the better offense at home. The best way to place a bet here is on the Brewers to win this game. 

Braves Brewers Prediction:  Our MLB Pick for Friday, August 21, 2026 (4:10 pm ET start time) is Brewers 2 Braves 1.

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Atlanta Braves: 41-41 (-10.9 units) on the moneyline against NL Central opponents. 239-214 (-44 units) on the moneyline in all games. 112-114 (-22.8 units) on the moneyline in road games. 14-7 UNDER on the road when the total is 7 or less.

Milwaukee Brewers: 272-192 (+50.6 units) on the moneyline in all games. 144-90 (+22.9 units) on the moneyline in home games. 173-105 (+21.8 units) on the moneyline as a favorite of -110 or higher. 23-10 UNDER against left-handed starters.

Atlanta Braves:  R. Lopez (SP) Fifteen Day IL - Knee. R. Suarez (RP) Fifteen Day IL - Elbow. S. Strider (SP) Sixty Day IL - Elbow. J. Wentz (RP) Sixty Day IL - Knee. J. Jimenez (RP) Sixty Day IL - Knee. S. Schwellenbach (SP) Sixty Day IL - Elbow.

Milwaukee Brewers:  A. Uribe (RP) Fifteen Day IL - Forearm. S. Frelick (RF) Ten Day IL - Shoulder. J. Romero (RP) Fifteen Day IL - Appendix. R. Zastryzny (RP) Sixty Day IL - Shoulder. B. Woodruff (SP) Sixty Day IL - Shoulder. J. Kuhnel (RP) Fifteen Day IL - Shoulder. Q. Priester (SP) Sixty Day IL - Wrist. B. Fitzpatrick (RP) Sixty Day IL - Elbow. A. Zerpa (RP) Sixty Day IL - Forearm.

"I thought he came out looking good, looking sharp. Fifth inning, I think the stuff wasn't quite as crisp. But look, he showed the talented arm that he is, and I think he's going to help us move forward. These TJ guys, it takes time … but he's a very talented kid." - Walt Weiss after his team’s loss against the Twins in their game on Wednesday. 

“Our guys nearly came back. They battled. We had some youthful at-bats in there. When you’re trying to make a comeback, that doesn’t help.” - Pat Murphy after his team’s loss against the Mariners in their game on Wednesday.

Ronald Acuña Jr. (R) RF

Drake Baldwin (L) DH

Matt Olson (L) 1B

Ozzie Albies (S) 2B

Lane Thomas (R) LF

Michael Harris II (L) CF

Mauricio Dubón (R) SS

Austin Riley (R) 3B

Sean Murphy (R) C

Brice Turang (L) 2B

Jackson Chourio (R) LF

Jake Bauers (L) 1B

Gary Sánchez (R) C

Christian Yelich (L) DH

Joey Ortiz (R) SS

Garrett Mitchell (L) CF

David Hamilton (L) 3B

Luis Lara (S) RF

Batting Average:  Jair Camargo (.500)

Hits:  Michael Harris (134)

Home Runs:  Matt Olson (36)

RBI:  Matt Olson (77)

Stolen Bases:  Ronald Acuña (16)

Wins:  Chris Sale (12)

Saves:  Raisel Iglesias (25)

ERA:  Hunter Stratton (0.00)

Batting Average:  Jihwan Bae (.500)

Hits:  Brice Turang (120)

Home Runs:  Jake Bauers (22)

RBI:  Brice Turang (75)

Stolen Bases:  David Hamilton (24)

Wins:  Aaron Ashby (13)

Saves:  Trevor Megill (22)

ERA:  Easton McGee (0.00)

Managers:

Atlanta Braves: Walt Weiss (1st season)

Milwaukee Brewers: Pat Murphy (3rd season)