Arkansas Razorbacks vs Duke Blue Devils Prediction, Picks and Game Preview - 11/27/2025

Game Time: 8:00 pm ET, Thursday, November 27, 2025

Venue:  United Center, Chicago, IL

Where to Watch:  CBS

DraftKings:  Point Spread:  Arkansas +10.5, Duke -10.5; Over/Under:  157.5 points

Bet365:  Point Spread:  Arkansas +10.5, Duke -10.5; Over/Under:  157.5 points

BetMGM:  Point Spread:  Arkansas +10.5, Duke -10.5; Over/Under:  157.5 points

Arkansas Razorbacks:  5-1 (0-0) (6th place, SEC)

Duke Blue Devils:  7-0 (0-0) (2nd place, ACC)

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Arkansas Razorbacks:  4-1  last 5

Duke Blue Devils:  5-0  last 5

Arkansas is entering this game with a 5-1 record overall, a 0-0 record in conference games, and they are 0-0 in their neutral site games this season where they will be in this game. They are coming off a win against the Jackson State Tigers in their last game. Malique Ewin led the team in points in that game with 21 while Karter Knox was next on the team with 17. Dajuan Wagner Jr. led the team in assists with 7 in that game while Karter Knox led the team in rebounds with 10. They were 63.9% from the field, 50% from 3-point range, and 77.8% from the free throw line with their shooting in that game. Their offense is averaging 91 PPG and their defense is allowing their opponents to average 70.2 PPG against them. Arkansas has an ATS record of 3-3 this season and their O/U record is 2-4.

Duke is entering this game with a 7-0 record overall, a 0-0 conference record, and they are 2-0 in their neutral site games this season where they will be in this game. They are coming off a win against the Howard Bison in their last game. Cameron Boozer led the team in points in that game with 26 while Patrick Ngongba II was next on the team with 16. Cameron Boozer led the team in assists with 6 in that game while Cameron Boozer led the team in rebounds with 12. They were 61% from the field, 28% from 3-point range, and 63.6% from the free throw line with their shooting in that game. Their offense is averaging 93.6 PPG and their defense is allowing their opponents to average 57 PPG against them. Duke has an ATS record of 6-1 this season and their O/U record is 1-6.

The current betting odds have Duke listed as a 10.5 point favorite in this game according to Draftkings Sportsbook. Duke has looked great in their games this season with their 7-0 record overall which has them ranked inside the top 5 teams in the nation. They have also played in 2 neutral site games this season and they are 2-0 in those. Meanwhile, Arkansas has looked good in their games this season with their 5-1 record overall which has them ranked inside the top 25 teams in the nation. They haven't really been tested in these kinds of games though with 5 of their 6 games being played at home. They are 0-1 in their road games this year, losing to Michigan State in the only game they left home for, and now they are playing their first neutral site game of the season. They did play a close game in that loss to Michigan State and they just beat up on Jackson State in their last one, but they have also been struggling lately. They have been playing in some really close games lately as they struggled to beat both Samford and Winthrop at home. Duke has been rolling over teams all season with the talent they have and they have been tested by some good teams too. Their strongest opponent was a game against Kansas, and they won that game by 12 points which is also their lowest margin of victory this season. The best way to place a bet here is on Duke to cover the spread in this game. 

Arkansas Duke Prediction:  Our NCAAB Pick for Thursday, November 27, 2025 (8:00 pm ET start time) is Duke 92 Arkansas 65.

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Arkansas Razorbacks: 5-10 ATS in all neutral court games. 7-21 ATS when the total is 150 to 159.5. 2-12 ATS after a win by 15 points or more. 5-17 ATS after scoring 85 points or more. 8-2 OVER as a neutral court underdog or pick.

Duke Blue Devils: 52-29 ATS in all games. 35-16 ATS as a favorite of 10 or more points. 21-8 ATS after scoring 85 points or more. 10-5 ATS after a game where they allowed a shooting pct. of 33% or less. 10-6 OVER after a game where they made 55% of their shots or better.

Arkansas Razorbacks:  None.

Duke Blue Devils:  S. Wilkins (G-F) Out - Redshirt.

“Look, I’ve got a lot of work to do with this group. Last year, the culture at the end of the year was right where I wanted it. Right now, the culture is not there because guys are still trying to do what they choose to do. You have a choice. You do what we’re asking you to do.” - John Calipari on his team this season. 

"[It was] an honor to have Kenny Blakeney back. Nate James, [I] spent a lot of time with Nate here as a player and as a coach. Kenny obviously, his success and what he has done at Duke and at Howard makes it just a big-time honor. I thought we did a lot of good things. They played incredibly hard even to the final second. A lot of the turnovers late; I think [that] came from a place of how hard they play and what their program stands for. The efficiency, particularly from Cam [Boozer] and Pat [Ngongba], if my math is right, they were 18-of-21 from the field. That was great, and we will continue to build and get ready for Thursday." - Jon Scheyer after his team’s win against Howard in their last game. 

D. Acuff 

T. Brazile 

N. Pringle 

B. Richmond 

D. Wagner

C. Boozer 

I. Evans 

C. Foster 

P. Ngongba 

D. Sarr

PPG: Meleek Thomas (18.3)

APG: Darius Acuff Jr. (4.3)

Reb/G: Trevon Brazile (7)

PPG: Cameron Boozer (21.1)

APG: Cameron Boozer (4)

Reb/G: Cameron Boozer (9.9)

Coaches:

Arkansas Razorbacks: John Calipari (2nd season)

Duke Blue Devils: Jon Scheyer (4th season)