by Rod Pearson
Thursday, Nov 20, 2025
Game Time: 8:00 pm ET, Saturday, November 22, 2025
Venue: Folsom Field, Boulder, CO
Where to Watch: ESPN2
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: ASU -7, Colorado +7; Over/Under: 47.5 points
Bet365: Point Spread: ASU -7, Colorado +7; Over/Under: 48.5 points
BetMGM: Point Spread: ASU -7, Colorado +7; Over/Under: 47.5 points
Season Record
Arizona State Sun Devils: 7-3 (5-2) (6th place, Big 12)
Colorado Buffaloes: 3-7 (1-6) (15th place, Big 12)
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Recent Form
Arizona State Sun Devils: won their last game at home against the West Virginia Mountaineers 25-23.
Colorado Buffaloes: lost their last game on the road against the West Virginia Mountaineers 29-22.
Arizona State Sun Devils vs Colorado Buffaloes Preview and Analysis
Arizona State is entering this game with a 7-3 record overall and they have a 5-2 record in their conference games too. They are 5-1 in their home games, 2-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against West Virginia 25-23. Jeff Sims was the starting QB and he completed 19/28 passes for 207 passing yards, 3 touchdowns, and 0 interceptions. Jeff Sims led the team in rushing yards with 81. Derek Eusebio led the receivers with 74 receiving yards on 6 receptions and 1 TD. Jordan Crook led the defense in that game with 10 solo tackles and 4 assisted tackles while Keyshaun Elliott, Justin Wodtly, and Anthonie Cooper each led the defense in sacks with 1. Keith Abney II came away with the only interception for them in that one.
Colorado is entering this game with a 3-7 record overall and they have a 1-6 record in their conference games too. They are 3-3 in their home games, 0-4 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against West Virginia 29-22. Julian Lewis was the starting QB and he completed 22/35 passes for 299 passing yards, 2 touchdowns, and 0 interceptions. Drelon Miller led the team in rushing yards with 42. Omarion Miller led the receivers with 131 receiving yards on 6 receptions and 1 TD. Jeremiah Brown led the defense in that game with 6 solo tackles and 5 assisted tackles while Brandon Davis-Swain and Arden Walker each led the defense in sacks with 1. John Slaughter and Preston Hodge each came away with 1 interception for them in that one.
Arizona State vs Colorado Prediction
The current betting odds have Arizona State listed as a 7 point favorite in this game according to Draftkings Sportsbook. Arizona State has looked good in their games this season with their 7-3 record overall and their 5-2 conference record which has them right near the top of the Big 12. They don't really have a shot at the CFP and they would need a miracle to make the Big 12 Championship, but they are still the defending champions of the conference and are currently ranked inside the top 25 too. Meanwhile, Colorado has looked terrible in their games this season with their 3-7 record overall and their 1-6 conference record which has them right near the bottom of the Big 12. They have been a disaster this season, but that was expected with the team losing their 2 best players to the NFL. They are off a 29-22 loss to West Virginia in their last one and that was a big loss for them since they are no longer bowl eligible with 7 losses. Their offense has struggled this season with a QB carousel, and the defense has been giving up a ton of points as they have gotten blown out in many games against better teams in the Big 12. Arizona State is missing their starting QB, but they found a way to beat West Virginia 25-23 in their last one and they are still playing with a lot of pride to end the year. Look for Arizona State to roll over a bad Colorado team that has been one of the worst in the Big 12 all season. The best way to place a bet here is on Arizona State to cover the spread in this game.
Arizona State Colorado Prediction: Our NCAAF Pick for Saturday, November 22, 2025 (8:00 pm ET start time) is Arizona State 20 Colorado 7.
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NCAAF Betting Trends
Arizona State Sun Devils: 21-13 ATS in all lined games. 9-5 ATS in road lined games. 16-8 ATS against conference opponents. 8-4 UNDER off a home win. 12-6 UNDER after playing a game at home.
Colorado Buffaloes: 3-6 ATS as an underdog of 3.5 to 10 points. 15-25 ATS at home after a game with a turnover margin of +2 or better. 9-5 UNDER off a loss against a conference rival.
Key Injuries
Arizona State Sun Devils: T. Nkuba (CB) Questionable - Undisclosed. A. Fall (CB) Doubtful - Undisclosed. G. Rigdon (RB) Out - Undisclosed. Z. Swanson (DL) Out - Undisclosed. J. Fortier (TE) Out - Undisclosed. I. Iosefa (LB) Out - Undisclosed. C. Arends (TE) Out - Undisclosed. N. Johnson (WR) Out - Undisclosed. K. Brown (RB) Out - Undisclosed. R. Bimage Jr. (CB) Out - Upper Body. C. Hunt (QB) Questionable - Undisclosed. J. Tyson (WR) Questionable - Hamstring. X. Alford (CB) Out - Undisclosed. Z. Fiaseu (LB) Out - Redshirt. S. Leavitt (QB) Out - Foot. B. Coleman (OG) Out - Arm.
Colorado Buffaloes: R. Johnson (CB) Out - Undisclosed. K. Salter (LB) Probable - Undisclosed. A. McPherson (DL) Probable - Undisclosed. Z. Atkins (TE) Probable - Undisclosed. L. Merritt (DL) Probable - Undisclosed. B. Davis-Swain (DL) Questionable - Undisclosed. J. Brown (LB) Questionable - Undisclosed. C. Stoutmire (S) Questionable - Undisclosed. M. Walker (LB) Doubtful - Undisclosed. T. Thomas (DL) Out - Undisclosed. C. Dempsey (LS) Out - Undisclosed. B. Finneseth (S) Out - Undisclosed. A. McNeill (DL) Out - Undisclosed. J. Seaton (OT) Questionable - Undisclosed. L. Johnson III (OG) Questionable - Undisclosed. M. Vickers (CB) Questionable - Undisclosed.
Notable Quotes
“Right now, we're getting it done. It's so cool watching these guys through all the adversity, it's like, 7-3, we're still in this thing.” - Kenny Dillingham after his team’s win against WVU in their last game.
"It felt amazing playing football again. But of course, it hurts to lose. We have to play better.” - Julian Lewis after their loss against WVU in their last game.
Starting Lineups
Arizona State Sun Devils
WR McClain, Malik
WR Tyson, Jordyn
WR Eusebio, Derek
TE Metayer, Chamon
TE Harpole, Cameron
QB Sims, Jeff
RB Brown, Raleek
Colorado Buffaloes
WR Miller, Omarion
WR Brown, Sincere
WR Williams, Joseph
TE Atkins, Zach
QB Lewis, Julian
RB Welch, Micah
Statistical Leaders
Arizona State Sun Devils
Passing: Sam Leavitt (1,628)
Rushing: Raleek Brown (823)
Receiving: Jordyn Tyson (628)
Touchdowns: Jordyn Tyson (9)
Colorado Buffaloes
Passing: Kaidon Salter (1,242)
Rushing: Micah Welch (313)
Receiving: Omarion Miller (652)
Touchdowns: Omarion Miller (7)
Coaches:
Arizona State Sun Devils: Kenny Dillingham (3rd season)
Colorado Buffaloes: Deion Sanders (3rd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
