Arizona Diamondbacks vs Cleveland Guardians Prediction, Preview and Odds - 08/01/2026

Game Time: 7:15 pm ET, Saturday, August 1, 2026

Venue:  Progressive Field, Cleveland, OH

Where to Watch:  MLB TV, FOX

DraftKings:  Moneyline odds:  Diamondbacks +136, Guardians -164; Over/Under:  8 runs

Bet365:  Moneyline odds:  Diamondbacks +140, Guardians -170; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Diamondbacks +135, Guardians -160; Over/Under:  8 runs

Arizona Diamondbacks:  57-52 (2nd place, NL West)

Cleveland Guardians:  56-54 (2nd place, AL Central)

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Arizona Diamondbacks:  6-4 last 10

Cleveland Guardians:  4-6 last 10

The Diamondbacks are entering this series off a win and won their 3-game series against the Pittsburgh Pirates 2-1 in their last series. They enter this game with a 57-52 record overall and have a road record of 26-30. This is the 2nd game of a 3-game series with the Guardians on Saturday with the series opener still to be played on Friday. Their offense ranks 21st in the MLB with a .706 OPS. Rookie pitcher Mitch Bratt is their starting pitcher on Friday while rookie pitcher Kohl Drake is making his start in this game on Saturday. He is 0-0 with a 5.00 ERA this season. His team lost their last game this season with him making an appearance. In his last MLB regular season appearance, he allowed 4 ER, 2 HR, and 2 BB with 1 SO on 5 hits through 4 IP against the Washington Nationals.

The Guardians are entering this series off a win and won their 3-game series against the Cincinnati Reds 2-1 in their last series. They enter this game with a 56-54 record overall and have a home record of 27-26. This is the 2nd game of a 3-game series with the Diamondbacks on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 30th in the MLB with a .679 OPS. Tanner Bibee is their starting pitcher on Friday while Parker Messick is making his start in this game on Saturday. He is 8-6 with a 2.59 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 0 walks with 6 strikeouts on 6 hits through 7.2 innings pitched against the Tampa Bay Rays.

The current betting odds have the Guardians listed as a favorite in this game according to Draftkings Sportsbook. The Guardians have looked good in their games this season with their 56-54 record overall which has them right near the top of the AL Central. They have looked better in their own ballpark too with their 27-26 home record this season. Meanwhile, the Diamondbacks have looked good in their games this season with their 57-52 record overall which has them right near the top of the NL West. They haven't been a good road team though with their 26-30 road record this year. The Diamondbacks are 6-4 in their last 10 games and they have looked great lately. Their pitching has been a lot better over the last week, but they are going to have more trouble in this one. The Guardians haven't looked that great lately, now 4-6 in their last 10 games, but they have some momentum on their side from winning their last series and they are going to have the better pitching matchup here too. The Guardians are going with Messick in this one and he has looked great this season. He is 8-6 with a 2.59 ERA and he has been one of their best starters this year. He is coming off another great start giving up 1 earned run which has been a common theme for him and the team has won 2 of their last 3 games with him starting too. The Diamondbacks are going with Drake in this one and he hasn't looked great this season. He is 0-0 with a 5.00 ERA and hasn't had many starts in his rookie season. He gave up 4 earned runs in his last start which has been a common theme for him in his few starts and the team lost that last game he started in. The Diamondbacks have the better offense here, but their offense has not looked great over the last week, starting to cool down now, and the Guardians have a big edge with their pitching staff here. The best way to place a bet here is on the Guardians to win this game. 

Diamondbacks Guardians Prediction:  Our MLB Pick for Saturday, August 1, 2026 (7:15 pm ET start time) is Guardians 6 Diamondbacks 3.

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Arizona Diamondbacks: 225-208 (+5.7 units) on the moneyline in all games. 107-110 (+10.1 units) on the moneyline in road games. 89-106 (+9.5 units) on the moneyline as an underdog of +100 or higher. 25-12 OVER against AL Central opponents.

Cleveland Guardians: 13-20 (-7 units) on the moneyline against NL West opponents. 83-76 (-10.6 units) on the moneyline vs. a team with a poor bullpen whose ERA is 4.20 or worse. 30-40 (-12.4 units) on the moneyline after 3 consecutive games versus an interleague opponent. 27-18 OVER vs. NL teams allowing 4.5 or more runs/game on the season.

Arizona Diamondbacks:  D. Jameson (RP) Fifteen Day IL - Hip. L. Gurriel Jr. (LF) Ten Day IL - Adductor. T. Troy (LF) Ten Day IL - Shoulder. Z. Gallen (SP) Fifteen Day IL - Elbow. J. Lawlar (LF) Ten Day IL - Hamstring. M. Soroka (SP) Fifteen Day IL - Lower-Body. R. Nelson (SP) Sixty Day IL - Elbow. B. Walston (SP) Sixty Day IL - Elbow. C. Mena (SP) Sixty Day IL - Shoulder. A. Puk (RP) Sixty Day IL - Elbow. C. Burnes (SP) Sixty Day IL - Elbow. J. Martinez (RP) Sixty Day IL - Elbow. A. Saalfrank (RP) Sixty Day IL - Shoulder.

Cleveland Guardians:  S. Armstrong (RP) Fifteen Day IL - Leg.

"We came here to do what we did -- win two out of three. And that's always our objective -- to win as many games as we possibly can. But after that first night -- it was a heartbreaking loss -- and then a big win [on Tuesday]." - Torey Lovullo after his team’s win against the Pirates in their game on Wednesday. 

“It was a huge series, especially coming off a tough weekend, a tough road trip. Just really proud of the guys.” - Stephen Vogt after his team’s win against the Reds in their game on Wednesday.

Corbin Carroll (L) RF

Geraldo Perdomo (S) SS

Gabriel Moreno (R) C

Ketel Marte (S) DH

Max Kepler (L) LF

Nolan Arenado (R) 3B

Tim Tawa (R) 1B

Ildemaro Vargas (S) 2B

Jorge Barrosa (S) CF

Steven Kwan (L) LF

José Ramírez (S) 3B

Chase DeLauter (L) RF

Travis Bazzana (L) DH

Brayan Rocchio (S) SS

Kyle Manzardo (L) 1B

Gabriel Arias (R) 2B

Patrick Bailey (S) C

Petey Halpin (L) CF

Batting Average:  Jordan Lawlar (.316)

Hits:  Ketel Marte (107)

Home Runs:  Ketel Marte (19)

RBI:  Ketel Marte (61)

Stolen Bases:  Geraldo Perdomo (17)

Wins:  Eduardo Rodriguez (10)

Saves:  Paul Sewald (24)

ERA:  Gerardo Carrillo (1.50)

Batting Average:  Austin Hedges (.282)

Hits:  Brayan Rocchio (99)

Home Runs:  Kyle Manzardo (13)

RBI:  Chase DeLauter (51)

Stolen Bases:  José Ramírez (26)

Wins:  Gavin Williams (10)

Saves:  Cade Smith (30)

ERA:  Colin Holderman (1.71)

Managers:

Arizona Diamondbacks: Torey Lovullo (10th season)

Cleveland Guardians: Stephen Vogt (3rd season)