Arizona Diamondbacks vs Chicago Cubs Prediction, Preview and Odds - 05/21/2022

by Amedeus Mastrangelo

Friday, May 20, 2022
Game Time: 2:20 pm ET, Saturday, May 21, 2022
Venue:  Wrigley Field, Chicago, IL
Where to Watch:  MARQ

 

Opening Odds at USA Sportsbooks

DraftKings:  Moneyline odds:  Diamondbacks +130, Cubs -150; Over/Under:  7.5 runs
Bet365:  Moneyline odds:  Diamondbacks +130, Cubs -150; Over/Under:  7.5 runs
BetMGM:  Moneyline odds:  Diamondbacks +130, Cubs -150; Over/Under:  7.5 runs
 

Season Record

Arizona Diamondbacks:  19-21 (5th place, NL West)
Chicago Cubs:  15-22 (4th place, NL Central)
 
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Arizona Diamondbacks vs Chicago Cubs Preview and Analysis

 
Recent Form
Arizona Diamondbacks:  3-7 last 10
Chicago Cubs:  6-4 last 10
 
 
 

Arizona Diamondbacks Analysis

The Diamondbacks are coming into this game with a 19-21 record overall and they are 9-10 in their road games this season where they will be in this game. They have lost 6 of their last 7 games but are coming into this one off of a win in their last game which snapped a 6 game losing streak that they were on. They just lost their 4-game series against the Los Angeles Dodgers getting swept 4-0 and they are playing the 3rd game of a 4-game series with the Cubs on Saturday. This will be the 3rd game of the series on Saturday with the 2nd game still to be played on Friday. Humberto Castellanos is the starting pitcher for them on Friday while Madison Bumgarner is on the mound for them here on Saturday. He is 2-2 with a 2.29 ERA this season. His team won 3 of their last 4 games this season with him as a starter. In his last start, he allowed 3 ER, 0 HRs, and 2 BB with 1 K on 6 hits in 5 IP against the Los Angeles Dodgers. They scored 16 runs in their last series averaging 4 runs scored per game in that span and they allowed 29 runs against them averaging just over 7 runs allowed per game.
 

Chicago Cubs Analysis

The Cubs are coming into this game with a 15-22 record overall and they are 6-13 in their home games this season where they will be in this game. They are coming into this game on a 2 game losing streak. They just won their 3-game series against the Pittsburgh Pirates 2-1 and they are playing the 3rd game of a 4-game series with the Cubs on Saturday. This will be the 3rd game of the series on Saturday with the 2nd game still to be played on Friday. Kyle Hendricks is the starting pitcher for them on Friday while Justin Steele will be on the mound for them here on Saturday. He is 1-4 with a 4.50 ERA this season. His team lost 4 of their last 5 games this season with him as a starter. In his last start, he allowed 1 earned run, 0 homers, and 2 BB with 10 strikeouts on 3 hits in 6 innings played against the Arizona Diamondbacks. They scored 18 runs in their last series averaging 6 runs scored per game in that span and they allowed 3 runs against them averaging 1 run allowed per game.
 

 

Diamondbacks vs Cubs Prediction

The Diamondbacks are coming into this game as an underdog with the current betting odds. They have been very inconsistent this season as they were very hot over a week ago and then cooled off completely, going on a losing streak that was just snapped in the first of this series. They are going up against a Cubs team here that has been winning more games recently but still has not played any better this season. The Cubs also have Steele on the mound here who has not been pitching well this season but is coming off of a good start in his last. The D-backs have Bumgarner on the mound though and he has yet to have a bad start this season as he has always been a good and reliable pitcher over the last few seasons. He gives the D-backs a very good chance to win this game as he will keep the Cubs from scoring a lot and could go very deep in this game. Steel has already shown that he can break down in a game and the D-backs have a decent lineup that have still been hitting the ball very well despite losing a lot of their last few games. The best bet here is on the D-backs to win this game as the value is on them here.
 
Diamondbacks Cubs Prediction:  Our MLB Pick for Saturday, May 21, 2022 (2:20 pm ET start time) is Diamondbacks 3 Cubs 1.
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MLB Betting Trends

 
Arizona Diamondbacks: 6-2 (+5.7 Units) ML as a road underdog of +100 to +150. 24-15 UNDER in all games. 27-18 UNDER as a road underdog of +100 to +150.
Chicago Cubs: 120-141 (-19.6 Units) ML in all games. 62-70 (-17.1 Units) ML in home games. 8-1 UNDER as a favorite of -110 or higher.
 

Key Injuries

 
Arizona Diamondbacks:  C. Hummel (LF) Out indefinitely - Illness. N. Ahmed (SS) Out indefinitely - Illness. C. Kelly (C) Late May - Oblique.
Chicago Cubs:  N. Madrigal (2B) Out indefinitely - Back. D. Bote (3B) Early June - Shoulder. J. Heyward (RF) Out indefinitely - Illness.
 
 

Notable Quotes

 
"There were some really, really touch-and-go moments overall for this game. But we execute at a very high level when we need to, and that's what we're all about." - Torey Lovullo after his team’s win against the Cubs on Thursday.
 
 
"They outpitched us tonight. I thought our guys fought hard." - David Ross after his team’s loss against the D-backs on Thursday.
 
 

Starting Lineups

 
Arizona Diamondbacks
Daulton Varsho (L) DH
Geraldo Perdomo (S) SS
Josh Rojas (L) 3B
Christian Walker (R) 1B
David Peralta (L) LF
Jake McCarthy (L) RF
Alek Thomas (L) CF
Yonny Hernandez (S) 2B
Grayson Greiner (R) C
 
Chicago Cubs
Rafael Ortega (L) RF
Willson Contreras (R) C
Ian Happ (S) LF
Frank Schwindel (R) DH
Alfonso Rivas (L) 1B
Patrick Wisdom (R) 3B
Jonathan Villar (S) 2B
Christopher Morel (R) CF
Ildemaro Vargas (S) SS
 

Statistical Leaders

 
Arizona Diamondbacks
Batting Average:  Alek Thomas (.316)
Hits:  Daulton Varsho (33)
Home Runs:  Christian Walker (9)
RBI:  Christian Walker (18)
Stolen Bases:  Daulton Varsho (3)
Wins:  Merrill Kelly (3)
Saves:  Mark Melancon (8)
ERA:  Carson Kelly (0.00)
 
Chicago Cubs
Batting Average:  Christopher Morel (.286)
Hits:  Ian Happ (31)
Home Runs:  Patrick Wisdom (6)
RBI:  Seiya Suzuki (18)
Stolen Bases:  Jonathan Villar (3)
Wins:  Mychal Givens (3)
Saves:  David Robertson (5)
ERA:  Brandon Hughes (0.00)
 
Managers:
Arizona Diamondbacks: Torey Lovullo (6th season)
Chicago Cubs: David Ross (3rd season)


Amedeus Mastrangelo

About the Author:

Amedeus Mastrangelo has been heavily wagering on all sports for years and plays just about everything, including sides, totals, favorites, underdogs, against the spread, alternative spreads, first half, second half, player props, and futures. The bottom line is, if Mastrangelo can see an edge in any way shape or form, then he's going to take advantage.

All photographic images used for editorial content have been licensed from the Associated Press.

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