by Rod Pearson
Friday, Nov 28, 2025
Game Time: 1:00 pm ET, Sunday, November 30, 2025
Venue: Raymond James Stadium, Tampa, FL
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Cardinals +3, Buccaneers -3; Over/Under: 43.5 points
Bet365: Point Spread: Cardinals +3, Buccaneers -3; Over/Under: 43.5 points
BetMGM: Point Spread: Cardinals +3, Buccaneers -3; Over/Under: 44 points
Season Record
Arizona Cardinals: 3-8 (4th place, NFC West)
Tampa Bay Buccaneers: 6-5 (1st place, NFC South)
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Arizona Cardinals: lost their last game at home against the Jacksonville Jaguars 27-24 in overtime.
Tampa Bay Buccaneers: lost their last game on the road against the Los Angeles Rams 34-7.
Arizona Cardinals vs Tampa Bay Buccaneers Preview and Analysis
The Cardinals are entering this game with a 3-8 record overall and they have a 0-4 record in their divisional games too. They are 1-5 in their home games, 2-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Jacksonville Jaguars 27-24 in OT. Jacoby Brissett was the starting QB and he completed 33/49 passes for 317 passing yards, 1 touchdown, and 0 interceptions. Michael Carter led the team in rushing yards with 28. Michael Wilson led the receivers with 118 receiving yards on 10 receptions. Jalen Thompson led the defense in that game with 6 solo tackles and 3 assisted tackles while Jalen Thompson and Jordan Burch each led the defense in sacks with 1. Budda Baker, Akeem Davis-Gaither, and Garrett Williams each came away with 1 interception for them in that one.
The Buccaneers are entering this game with a 6-5 record overall and they have a 2-0 record in their divisional games too. They are 2-2 in their home games, 4-3 in their road games, and they are also 1-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Los Angeles Rams 34-7. Baker Mayfield was the starting QB and he completed 9/19 passes for 41 passing yards, 1 touchdown, and 2 interceptions. Sean Tucker led the team in rushing yards with 42. Emeka Egbuka led the receivers with 32 receiving yards on 3 receptions. Lavonte David led the defense in that game with 4 solo tackles and 4 assisted tackles while YaYa Diaby led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
Cardinals vs Buccaneers Prediction
The current betting odds have the Buccaneers listed as a 3 point favorite in this game according to Draftkings Sportsbook. The Buccaneers have looked good in their games this season with their 6-5 record overall which has them right at the top of the NFC South. They haven't looked great on their home field though with their 2-2 home record this season. Meanwhile, the Cardinals haven't looked good in their games this season with their 3-8 record overall which has them right at the bottom of the NFC West. They haven't been a good road team this year either, but they have looked better in those with their 2-3 road record. The Cardinals have been a disaster this season, dealing with a ton of injuries. They have been missing Kyler Murray for a few games and the offense hasn't looked bad with Brissett, but they have still been really up and down. The defense also started the season playing well, but they have taken a dive lately with a lot of blow out losses. They are off a 27-24 loss to the Jags in their last one, but they still found a way to lose the game at home, even with the Jags turning the ball over a lot. The Buccaneers haven't looked any better lately with 3 losses in a row now and they have also been dealing with their own injuries too. They are off a 34-7 loss to the Rams in their last one and that game was over quickly, but now they are back at home with some key players coming back to the lineup. The Buccaneers need this game more with the Panthers creeping up on them in the division, and they should be able to take advantage of a banged up Cardinals team. The best way to place a bet here is on the Buccaneers to cover the spread in this game.
Cardinals Buccaneers Prediction: Our NFL Pick for Sunday, November 30, 2025 (1:00 pm ET start time) is Buccaneers 27 Cardinals 20.
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NFL Betting Trends
Arizona Cardinals: 43-62 ATS after a game with a turnover margin of +2 or better. 10-16 ATS on the road against NFC South division opponents. 8-14 ATS on the road after 3 or more consecutive losses against the spread. 8-3 OVER after a loss by 6 or less points. 5-1 OVER vs. bad defensive teams who give up 24 or more points/game.
Tampa Bay Buccaneers: 4-1 ATS against NFC West division opponents. 6-2 ATS after scoring 14 points or less last game. 9-5 ATS when playing against a team with a losing record. 4-1 OVER when playing against a bad team (Win Pct. 25% to 40%). 4-1 OVER after a game with a turnover margin of -2 or worse.
Key Injuries
Arizona Cardinals: K. Beachum (OG) Injured - Groin. J. Sweat (LB) Injured - Eye. W. Hernandez (OG) Injured - Hip. B. Browning (LB) Injured - Concussion. E. Demercado (RB) Injured - Ankle. B. Knight (RB) Injured - Knee. K. Clark (CB) Injured - NIR-Personal. M. Melton (CB) Injured - Heel. C. Jones (OG) Injured - Knee. X. Weaver (WR) Injured - Shoulder. M. Harrison Jr. (WR) Injured - Illness. D. Taylor-Demerson (S) Injured - Ankle. T. Benson (RB) Injured - Knee. H. Conner (OG) Injured - Knee. W. Nolen III (DL) Injured - Knee. W. Johnson (CB) Injured - Back.
Tampa Bay Buccaneers: H. Reddick (LB) Injured - Ankle. S. Shepard (WR) Injured - Shoulder. C. Godwin Jr. (WR) Injured - Fibula. B. Mayfield (QB) Injured - Shoulder. J. Dean (CB) Injured - Hip. A. Nelson (LB) Injured - Ribs. T. Wirfs (OT) Injured - Shoulder. B. Bredeson (OG) Injured - Hamstring. R. Wisdom (S) Injured - Quad. B. Irving (RB) Injured - Shoulder. B. Morrison (CB) Injured - Hamstring.
Notable Quotes
“We were trying to go win a game. I've got to make a better throw.” - Jacoby Brissett after their loss against the Jaguars in their last game.
“They just executed. And they executed, I mean, from the play-calling to the quarterback to the receivers to the offensive line to the defensive front and the secondary, they out-executed us and they outplayed us.” - Todd Bowles after his team’s loss against the LA Rams in their last game.
Starting Lineups
Arizona Cardinals
WR Weaver, Xavier
WR Wilson, Michael
WR Dortch, Greg
TE McBride, Trey
QB Brissett, Jacoby
RB Knight, Bam
Tampa Bay Buccaneers
WR Egbuka, Emeka
WR Johnson, Tez
WR Godwin Jr., Chris
TE Otton, Cade
QB Mayfield, Baker
RB Irving, Bucky
Statistical Leaders
Arizona Cardinals
Passing: Jacoby Brissett (1,887)
Rushing: Emari Demercado (241)
Receiving: Trey McBride (797)
Touchdowns: Trey McBride (7)
Tampa Bay Buccaneers
Passing: Baker Mayfield (2,406)
Rushing: Rachaad White (414)
Receiving: Emeka Egbuka (749)
Touchdowns: Emeka Egbuka (6)
Coaches:
Arizona Cardinals: Jonathan Gannon (3rd season)
Tampa Bay Buccaneers: Todd Bowles (4th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
