Arizona Cardinals vs Seattle Seahawks Prediction, Preview and Odds - 11/21/2021

by Amedeus Mastrangelo

Game Time: 4:25 pm ET, Sunday, November 21, 2021
Venue:  Lumen Field, Seattle, WA 
Where to Watch:  Fox

 

Opening Odds at USA Sportsbooks

DraftKings:  Point Spread:  Cardinals -2.5, Seahawks +2.5; Over/Under:  49 points
Bet365:  Point Spread:  Cardinals -2.5, Seahawks +2.5; Over/Under:  49 points
BetMGM:  Point Spread:  Cardinals -2.5, Seahawks +2.5; Over/Under:  49.5 points
 

Season Record

Arizona Cardinals:  8-2 (1st place, NFC West)
Seattle Seahawks:  3-6 (4th place, NFC West)
 
Do not miss out on our expert handicapper analysis! Al McMordie has had 9 straight winning NFL seasons (2012-2020)! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

 

Arizona Cardinals vs Seattle Seahawks Preview and Analysis

 
Recent Form
Arizona Cardinals:  lost at home on Nov. 14 against the Carolina Panthers 34-10.
Seattle Seahawks:  lost on the road on Nov. 14 against the Green Bay Packers 17-0.
 
 
 

Arizona Cardinals Analysis

The Cardinals are coming into this game with an 8-2 record overall and they are 5-0 in their road games this season where they will be in this game. This will be their 4th divisional game of the year and they are currently 3-0 in their division games this season with wins against the LA Rams and the San Francisco 49ers twice. They have lost 2 of their last 3 games and are coming into this one off of a loss in their last game. Kyler Murray and Deandre Hopkins did not play in their last game due to injury. Colt McCoy was the starting quarterback and he did not play well as he completed 11/20 passes for 107 yards and 1 interception. He also got injured at one point in that game so Chris Streveler had to step in and he completed 6/9 passes for 36 yards. James Conner led the team in rushing with 39 yards and 1 touchdown on 10 carries. Christian Kirk led the receivers with 58 yards on 7 receptions in what was a quiet day for the receiving corps. Jordan Hicks led the defense in that game with 8 solo tackles and 2 assisted ones. No one on the defense recorded a sack in that game but Jalen Thompson came up with the only interception for them in that one. They have scored 287 points in their 10 games this season averaging 28.7 PPG and they have allowed their opponents to score 189 points against them allowing 18.9 PPG. Their offense is averaging 375.5 YPG while their defense is allowing 323 YPG.
 
 

Seattle Seahawks Analysis

The Seahawks are coming into this game with a 3-6 record overall and they are 1-3 in their home games this season where they will be in this game. This will be the 3rd divisional game on their schedule this year and they are currently 1-1 in their division games this season. They have lost 4 of their last 5 games and are coming into this one off of another loss in their last game. Russell Wilson did not play well in their last game and he was shut out for the first time in his career as he completed 20/40 passes for 161 yards and 2 interceptions. Alex Collins led the team in rushing with 41 yards on 10 carries. Gerald Everett led the receivers with 63 yards on 8 receptions in what was a pretty quiet day for the receiving corps. Jordyn Brooks led the defense in that game with 9 solo tackles and 3 assisted ones. Rasheem Green recorded the only sack in that game for them while Jamal Adams came up with the only interception for them in that one. They have scored 181 points in their 9 games this season averaging 20.1 PPG and they have allowed their opponents to score 186 points against them allowing 20.7 PPG. Their offense is averaging 302.2 YPG while their defense is allowing 400.6 YPG.
 
 

 

Cardinals vs Seahawks Prediction

The Cardinals are coming into this game as a 2.5 point favorite with the current betting odds according to Draftkings Sportsbook. The Cardinals are coming off of a bad loss in their last game but they were missing their starting quarterback and their star wide receiver for that game. They will likely be back for this game and the Seahawks have not been playing well. They were struggling with Geno Smith taking over but Wilson just came back from injury and he did not play well at all getting shut out for the first time in his career in their loss to the Packers. This is a very important game and the Cardinals will go all out here as they rested players in their last game to have them ready for this one. The Cardinals have a lot more talent on their team right now and they are playing much better as a team when they have their starters in. The best bet to place in this game is on the Cardinals to cover the spread as they will come out in this game and make sure they get to 4-0 in the division, pretty much locking it up at that point.
 
Cardinals Seahawks Prediction:  Our NFL Pick for Sunday, November 21, 2021 (4:25 pm ET start time) is Cardinals 34 Seahawks 17.
Don't miss our champion handicappers free picks and expert football picks today.  And if you enjoyed this Arizona Cardinals Seattle Seahawks prediction, be sure to drop by every day for our weekly NFL predictions and previews.
 

NFL Betting Trends

 
Arizona Cardinals: 235-242 ATS in all games. 71-94 ATS as a favorite. 20-23 ATS as a road favorite. 116-120 ATS in road games. 120-124 ATS in games played on turf. 52-60 ATS in November games.
Seattle Seahawks: 93-84 ATS in games where the line is +3 to -3. 246-237 ATS in all games. 121-106 ATS as an underdog. 42-32 ATS as a home underdog. 129-114 ATS in home games. 187-184 ATS against conference opponents.
 

Key Injuries

 
Arizona Cardinals:  K. Murray (QB) Ques Sun - Ankle injury. D. Hopkins (WR) Ques Sun - Hamstring injury. C. McCoy (QB) Ques Sun - Pectoral injury. C. Edmonds (RB) Out indefinitely - Ankle injury.
Seattle Seahawks:  N. Warrior (CB) Ques Sun - Undisclosed injury. C. Carson (RB) Ques Sun - Neck injury. C. Barton (LB) Ques Sun - Quadricep injury.
 

Notable Quotes

 
"I knew what the coverage was, what we were tying to do. It was just the timing and rhythm of it all. It just never clicked. The run game never could get going and you change your plan a little bit when you are down 17 points in the first half." - Colt McCoy on their loss to the Panthers in their last game.
 
 
"It's a big opportunity that we missed out on. Just disappointing, because this was a real shot. We could feel it and we knew it." - Pete Carroll on his team’s loss against the Packers in their last game.
 
 

Starting Lineups

 
Arizona Cardinals
WR GREEN, AJ 
WR Hopkins, DeAndre 
WR Kirk, Christian 
TE ERTZ, ZACH
QB Murray, Kyler 
RB Conner, James 
 
Seattle Seahawks
WR Metcalf, DK 
WR Lockett, Tyler 
TE Everett, Gerald 
QB WILSON, RUSSELL 
RB Penny, Rashaad 
FB BELLORE, NICK 
 

Statistical Leaders

 
Arizona Cardinals
Passing: K. Murray (2276)
Rushing: J. Conner (493)
Receiving: C. Kirk (603)
Touchdowns: J. Conner (11)
 
Seattle Seahawks
Passing: R. Wilson (1357)
Rushing: A. Collins (345)
Receiving: D. Metcalf (606)
Touchdowns: D. Metcalf (8)
 
Coaches:
Arizona Cardinals: Kliff Kingsbury (3rd season)
Seattle Seahawks: Pete Carroll (12th season)


Amedeus Mastrangelo

About the Author:

Amedeus Mastrangelo has been heavily wagering on all sports for years and plays just about everything, including sides, totals, favorites, underdogs, against the spread, alternative spreads, first half, second half, player props, and futures. The bottom line is, if Mastrangelo can see an edge in any way shape or form, then he's going to take advantage.

All photographic images used for editorial content have been licensed from the Associated Press.

© 2021 Al McMordie's BigAl.com. All Rights Reserved.