by Rod Pearson
Friday, Nov 07, 2025
Game Time: 4:05 pm ET, Sunday, November 9, 2025
Venue: Lumen Field, Seattle, WA
Where to Watch: CBS
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Cardinals +6.5, Seahawks -6.5; Over/Under: 44.5 points
Bet365: Point Spread: Cardinals +7, Seahawks -7; Over/Under: 45 points
BetMGM: Point Spread: Cardinals +7, Seahawks -7; Over/Under: 45 points
Season Record
Arizona Cardinals: 3-5 (4th place, NFC West)
Seattle Seahawks: 6-2 (1st place, NFC West)
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Recent Form
Arizona Cardinals: won their last game on the road against the Dallas Cowboys 27-17.
Seattle Seahawks: won their last game on the road against the Washington Commanders 38-14.
Arizona Cardinals vs Seattle Seahawks Preview and Analysis
The Cardinals are entering this game with a 3-5 record overall and they have a 0-2 record in their divisional games too. They are 1-3 in their home games, 2-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Dallas Cowboys 27-17. Jacoby Brissett was the starting QB and he completed 21/31 passes for 261 passing yards, 2 touchdowns, and 0 interceptions. Emari Demercado led the team in rushing yards with 79. Marvin Harrison Jr. led the receivers with 96 receiving yards on 7 receptions and 1 TD. Denzel Burke and Will Johnson each led the defense in that game with 5 solo tackles and 1 assisted tackle while Calais Campbell and Josh Sweat each led the defense in sacks with 2. Denzel Burke came away with the only interception for them in that one.
The Seahawks are entering this game with a 6-2 record overall and they have a 1-1 record in their divisional games too. They are 2-2 in their home games, 4-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Washington Commanders 38-14. Sam Darnold was the starting QB and he completed 21/24 passes for 330 passing yards, 4 touchdowns, and 1 interception. Kenneth Walker III led the team in rushing yards with 42. Jaxon Smith-Njigba led the receivers with 129 receiving yards on 8 receptions. Devon Witherspoon led the defense in that game with 5 solo tackles and 2 assisted tackles while Drake Thomas and Leonard Williams each led the defense in sacks with 1. Ty Okada came away with the only interception for them in that one.
Cardinals vs Seahawks Prediction
The current betting odds have the Seahawks listed as a 6.5 point favorite in this game according to Draftkings Sportsbook. The Seahawks have looked really good in their games this season with their 6-2 record overall which has them right at the top of the NFC West. They are off a 38-14 win over the Commanders in their last one and they have been rolling in their games lately. Meanwhile, the Cardinals haven't looked great in their games this season with their 3-5 record overall which has them right at the bottom of the NFC West. They are off a 27-17 win over the Cowboys in their last one and they needed that win after blowing some late leads over the last few weeks, but they still aren't in a great situation here. They beat the Cowboys on the road Monday night so they are already on a shorter week and the Seahawks are starting to look like one of the best teams in the NFL. The Cardinals offense has looked a lot better with Brissett starting at QB, but their back field has been a revolving door this year. The Seahawks have one of the best defenses in the NFL that is going to cause a lot of issues for this Cardinals offense, and the Seahawks still have the much better offense too. The Cardinals haven't looked terrible over the last few weeks, but this Seahawks team has been rolling and they aren't going to be stopped again by the worst team in their division. The best way to place a bet here is on the Seahawks to cover the spread in this game.
Cardinals Seahawks Prediction: Our NFL Pick for Sunday, November 9, 2025 (4:05 pm ET start time) is Seahawks 31 Cardinals 17.
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NFL Betting Trends
Arizona Cardinals: 25-17 ATS in all games. 10-2 ATS as a road underdog of 7 points or less. 21-14 ATS in all games where the total is between 42.5 and 49 points. 7-3 UNDER as a road underdog of 7 points or less. 6-2 UNDER in games played on turf.
Seattle Seahawks: 1-4 ATS after 3 or more consecutive wins against the spread. 7-14 ATS in home games. 4-9 ATS as a favorite of 3.5 to 9.5 points. 10-4 UNDER versus division opponents. 6-2 UNDER after scoring 30 points or more last game.
Key Injuries
Arizona Cardinals: B. Baker (S) Injured - Hamstring. Z. Jones (WR) Injured - Knee. K. Beachum (OG) Injured - Rest. M. Wilson Sr. (LB) Injured - Ribs. W. Hernandez (OG) Injured - Knee. K. Clark (CB) Injured - Ankle. B. Ojulari (LB) Injured - Knee. M. Melton (CB) Injured - Concussion. X. Weaver (WR) Injured - Ankle. K. Crawford (S) Injured - Hamstring. W. Johnson (CB) Injured - Back.
Seattle Seahawks: J. Reed (DL) Injured - Wrist. C. Kupp (WR) Injured - Hamstring. J. Jobe (CB) Injured - Concussion. J. Bobo (WR) Injured - Calf. E. Jones IV (LB) Injured - Knee. D. Young (WR) Injured - Quadricep. A. Barner (TE) Injured - Calf. C. Haynes (OG) Injured - Pectoral. T. Horton (WR) Injured - Groin. E. Arroyo (TE) Injured - Elbow.
Notable Quotes
“Believe me when I say it: I'm not surprised. We watch Sam every day and how he operates. He's the same guy every day, which is what you love about him. We're chasing it. The guys are determined, and it's fun to watch.” - Mike Macdonald after his team’s win against the Commanders in their last game.
“I’m looking at my watch, and I don’t remember the last time we won. It falls on me. At the bye, I was sitting in the shower, thinking about, ‘How did I let this happen?’ Everybody in there takes that attitude.” - Jonathan Gannon after his team’s win against the Cowboys in their last game.
Starting Lineups
Arizona Cardinals
WR Harrison Jr., Marvin
WR Jones, Zay
WR Wilson, Michael
TE McBride, Trey
QB Brissett, Jacoby
RB Knight, Bam
Seattle Seahawks
WR Smith-Njigba, Jaxon
WR Shaheed, Rashid
WR Horton, Tory
TE Barner, AJ
QB Darnold, Sam
RB Charbonnet, Zach
FB Ouzts, Robbie
Statistical Leaders
Arizona Cardinals
Passing: Kyler Murray (962)
Rushing: Kyler Murray (173)
Receiving: Marvin Harrison Jr. (492)
Touchdowns: Trey McBride (5)
Seattle Seahawks
Passing: Sam Darnold (2,084)
Rushing: Kenneth Walker III (472)
Receiving: Jaxon Smith-Njigba (948)
Touchdowns: Zach Charbonnet (5)
Coaches:
Arizona Cardinals: Jonathan Gannon (3rd season)
Seattle Seahawks: Mike Macdonald (2nd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
