by Rod Pearson
Wednesday, Sep 27, 2023
Game Time: 4:25 pm ET, Sunday, October 1, 2023
Venue: Levi's Stadium, Santa Clara, CA
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Cardinals +14, 49ers -14; Over/Under: 44 points
Bet365: Point Spread: Cardinals +14, 49ers -14; Over/Under: 44 points
BetMGM: Point Spread: Cardinals +14, 49ers -14; Over/Under: 44 points
Season Record
Arizona Cardinals: 1-2 (4th place, NFC West)
San Francisco 49ers: 3-0 (1st place, NFC West)
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Recent Form
Arizona Cardinals: won their last game at home against the Dallas Cowboys 28-16.
San Francisco 49ers: won their last game at home against the New York Giants 30-12.
Arizona Cardinals vs San Francisco 49ers Preview and Analysis
The Cardinals are entering this game with a 1-2 record overall and they have a 0-0 record in their divisional games too. They are 1-1 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Dallas Cowboys 28-16. Joshua Dobbs was the starting QB and he completed 17/21 passes for 189 passing yards, 1 touchdown, and 0 interceptions. James Conner led the team in rushing yards with 98 and 1 TD. Michael Wilson led the receivers with 86 receiving yards on 2 receptions. Kyzir White led the defense in that game with 8 solo tackles and 6 assisted tackles while Victor Dimukeje and Zaven Collins each led the defense in sacks with 1. Kyzir White came away with the only interception for them in that game.
The 49ers are entering this game with a 3-0 record overall and they have a 1-0 record in their divisional games too. They are 1-0 in their home games, 2-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the New York Giants 30-12. Brock Purdy was the starting QB and he completed 25/37 passes for 310 passing yards, 2 touchdowns, and 0 interceptions. Christian McCaffrey led the team in rushing yards with 85 and 1 TD. Deebo Samuel led the receivers with 129 receiving yards on 6 receptions and 1 TD. Oren Burks, Dre Greenlaw, Tashaun Gipson Sr., and Deommodore Lenoir each led the defense in that game with 4 solo tackles and 1 assisted tackle while Nick Bosa and Javon Hargrave each led the defense in sacks with 1. Talanoa Hufanga came away with the only interception for them in that game.
Cardinals vs 49ers Prediction
The current betting odds have the Cardinals listed as a 14 point underdog in this game according to Draftkings Sportsbook. The Cardinals are 1-2 this season and for a team that was projected to be one of the worst in the NFL this year, they haven't looked bad in their 3 games. They almost won on the road in Washington week 1 and they had a huge lead over the Giants in week 2 in a game they should have won but collapsed in. They held up last week though in their win against the Cowboys and now they are going to have momentum with them coming into this divisional game. The 49ers are 1 of 3 teams in the NFL that are 3-0 right now and they have looked really good on both sides of the ball in all 3 of their games. They have a lot of talented players on offense and defense but these two teams play each other a lot so the Cardinals are going to fight to keep this a closer game. Shanahan has also never faced the Cardinals with Gannon coaching and Dobbs at QB so the Cardinals have a bit of an advantage there. The 49ers are also a 14 point favorite here and a double digit spread is really tough for any team in the NFL to cover. The best way to place a bet here is on the Cardinals to cover the spread in this game.
Cardinals 49ers Prediction: Our NFL Pick for Sunday, October 1, 2023 (4:25 pm ET start time) is 49ers 23 Cardinals 13.
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NFL Betting Trends
Arizona Cardinals: 5-10 ATS off an upset win by 10 or more as a home underdog. 1-9 ATS after gaining 150 or more rushing yards in 2 straight games. 8-3 UNDER off a huge upset win as a double digit underdog. 11-5 UNDER after playing a game at home.
San Francisco 49ers: 27-15 ATS in all games. 13-5 ATS as a home favorite. 22-9 ATS against conference opponents. 6-1 UNDER as a home favorite of 7.5 to 14 points. 16-10 UNDER in all games where the total is between 42.5 and 49 points.
Key Injuries
Arizona Cardinals: J. Woods (LB) Ques Sun - Ankle. K. Barnes (LB) Ques Sun - Hand. Z. Collins (LB) Ques Sun - Eye. B. Baker (S) Out indefinitely - Hamstring. C. Watkins (DT) Out indefinitely - Bicep. L. Collier (DL) Out indefinitely - Bicep. M. Sanders (LB) Out indefinitely - Hand. D. Daley (OL) Out indefinitely - Ankle. J. Gaines II (OL) I-R - Knee. K. Murray (QB) Out indefinitely - Knee. P. Elflein (OL) I-R - Undisclosed. R. Fenton (CB) I-R - Undisclosed. M. Mack (RB) I-R - Achilles. G. Williams (CB) Out indefinitely - Knee. M. Hembrough (LS) I-R - Back.
San Francisco 49ers: A. Thomas (CB) Ques Sun - Knee. B. Aiyuk (WR) Ques Sun - Shoulder. D. Samuel (WR) Ques Sun - Ribs. D. Greenlaw (LB) Ques Sun - Ankle. S. Womack III (CB) Out indefinitely - Knee. R. Beal Jr. (DL) Out indefinitely - Hamstring. D. Gray (WR) Out indefinitely - Shoulder. D. Luter Jr. (CB) Out indefinitely - Knee. C. Latu (TE) I-R - Knee.
Notable Quotes
“Hopefully one of many. Back to the drawing board tomorrow.” - Jonathan Gannon after his team’s win against the Cowboys in their last game.
“I thought it was just a huge challenge, one of the bigger ones Brock has been in with a short week to prepare for a scheme like that. There's not a comfortable play throughout the game. ... I thought he settled down as the game went on." - Kyle Shanahan after his team’s win against the Giants in their last game.
Starting Lineups
Arizona Cardinals
WR Brown, Marquise
WR Wilson, Michael
WR Moore, Rondale
TE ERTZ, ZACH
QB Dobbs, Joshua
RB Conner, James
San Francisco 49ers
WR Aiyuk, Brandon
WR Samuel, Deebo
WR Jennings, Jauan
TE Kittle, George
QB Purdy, Brock
RB McCaffrey, Christian
FB JUSZCZYK, KYLE
Statistical Leaders
Arizona Cardinals
Passing: J. Dobbs (549)
Rushing: J. Conner (266)
Receiving: M. Wilson (161)
Touchdowns: J. Conner (2)
San Francisco 49ers
Passing: B. Purdy (736)
Rushing: C. McCaffrey (353)
Receiving: D. Samuel (247)
Touchdowns: C. McCaffrey (3)
Coaches:
Arizona Cardinals: Jonathan Gannon (1st season)
San Francisco 49ers: Kyle Shanahan (7th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
