Arizona Cardinals vs New York Giants Prediction, Preview and Odds - 10/04/2026

Game Time: 1:00 pm ET, Sunday, October 4, 2026

Venue:  MetLife Stadium, East Rutherford, NJ

Where to Watch:  CBS

DraftKings:  Point Spread:  Cardinals -1.5, Giants +1.5; Over/Under:  44.5 points

Bet365:  Point Spread:  Cardinals -1, Giants +1; Over/Under:  44.5 points

BetMGM:  Point Spread:  Cardinals -1, Giants +1; Over/Under:  44.5 points

Arizona Cardinals:  1-2 (3rd place, NFC West)

New York Giants:  2-1 (1st place, NFC East)

Do not miss out on our expert handicapper analysis! Hollywood Sports is on a HOT STREAK in the NFL on a 17-7-1 NFL RUN for +$9,090 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Arizona Cardinals:  lost their last game on the road against the San Francisco 49ers 36-30.

New York Giants:  won their last game at home against the Tennessee Titans 12-7.

The Cardinals are entering this game with a 1-2 record overall and they have a 0-2 record in their divisional games too. They are 0-1 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the San Francisco 49ers 36-30. Jacoby Brissett was the starting QB and he completed 38/52 passes for 280 passing yards, 2 touchdowns, and 0 interceptions. Jeremiyah Love led the team in rushing yards with 90. Michael Wilson led the receivers with 89 receiving yards on 11 receptions and 1 TD. Andrew Wingard led the defense in that game with 10 solo tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.

 

 

 

The Giants are entering this game with a 2-1 record overall and they have a 1-0 record in their divisional games too. They are 2-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Tennessee Titans 12-7. Jameis Winston was the starting QB and he completed 14/22 passes for 118 passing yards, 0 touchdowns, and 0 interceptions. Cameron Skattebo led the team in rushing yards with 60. Cameron Skattebo led the receivers with 40 receiving yards on 3 receptions. Arvell Reese led the defense in that game with 13 solo tackles while no one on the defense recorded a sack for them. Jevon Holland came away with the only interception for them in that one.

The current betting odds have the Cardinals listed as a 1.5 point favorite in this game according to Draftkings Sportsbook. The Cardinals haven't looked good in their games this season with their 1-2 record overall which has them right near the bottom of the NFC West. They haven't been a bad road team though with their 1-1 road record so far. Meanwhile, the Giants have looked good in their games this season with their 2-1 record overall which has them right near the top of the NFC East. They have looked great on their home field too with their 2-0 home record this season. The Giants have had a promising start to the season, beating the Cowboys in their season opener and sending a message to the rest of the NFL with their new head coach. They ended up getting destroyed by the Rams in week 2 though, even losing their starting QB for the season, and now things don't look nearly as good for them. They are coming off a 12-7 win over the Titans in their last one and they managed to get the job done with Winston starting at QB, but they barely beat one of the worst teams in the NFL and couldn't even score a TD in that one. The Cardinals definitely haven't been a good team in the NFL for years now, but they look like they have some life now with this new head coach. They shocked in their season opener with an upset win over the Chargers and now they have lost 2 games in a row, but those losses were against the Seahawks and the 49ers who both look like 2 of the best teams in the NFL. They are coming off a 36-30 loss to the 49ers in their last one and they were down big, but they never gave up in that game and kept coming back late, making it a game. They have a lot of talented players on offense too and Brissett has been a solid QB for them, they can take advantage of the QB troubles that the Giants are going through. The best way to place a bet here is on the Cardinals to cover the spread in this game. 

Cardinals Giants Prediction:  Our NFL Pick for Sunday, October 4, 2026 (1:00 pm ET start time) is Cardinals 21 Giants 13.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Arizona Cardinals New York Giants prediction, be sure to drop by every day for our weekly NFL predictions and previews.

Arizona Cardinals: 11-4 ATS in a road game where the total is between 42.5 and 49 points. 31-18 ATS against NFC East division opponents. 7-4 ATS after a loss by 6 or less points. 7-3 OVER as a favorite. 8-3 UNDER in games where the line is +3 to -3. 

New York Giants: 4-8 ATS in games where the line is +3 to -3. 5-12 ATS in all games where the total is between 42.5 and 49 points. 3-8 ATS vs. bad defensive teams who give up 24 or more points/game. 64-36 UNDER after a win by 6 or less points. 70-49 UNDER after a game with a turnover margin of +2 or better.

Arizona Cardinals:  None.

New York Giants:  None.

“Any time in the first half when we got something going, and then we’d have self-inflicted wounds. Against good teams, it’s like being a death wish. Against good teams, you can’t do that. You can’t beat yourself and try to beat them.” - Jacoby Brissett after their loss against the 49ers in their last game. 

“Today is the only day that we have, and today it was enough. I’ve had games where I’ve thrown for 500 yards, and the game didn’t turn out the way I wanted it to be. Any time, any day, I would rather win.” - Jameis Winston after their win against the Titans in their last game. 

WR Harrison Jr., Marvin

WR Wilson, Michael

WR Bourne, Kendrick

TE McBride, Trey

QB Brissett, Jacoby

RB Love, Jeremiyah

WR Nabers, Malik

WR Fields, Malachi

WR Mooney, Darnell

TE Likely, Isaiah

QB Winston, Jameis

RB Skattebo, Cam

FB Ricard, Patrick

Passing: Jacoby Brissett (652)

Rushing: Jeremiyah Love (160)

Receiving: Trey McBride (211)

Touchdowns: Trey McBride (2)

Passing: Jaxson Dart (250)

Rushing: Cam Skattebo (177)

Receiving: Isaiah Likely (124)

Touchdowns: Isaiah Likely (2)

Coaches:

Arizona Cardinals: Mike LaFleur (1st season)

New York Giants: John Harbaugh (1st season)