Arizona Cardinals vs Houston Texans Prediction, Preview and Odds - 12/14/2025

Game Time: 1:00 pm ET, Sunday, December 14, 2025

Venue:  NRG Stadium, Houston, TX 

Where to Watch:  FOX

DraftKings:  Point Spread:  Cardinals +10, Texans -10; Over/Under:  42.5 points

Bet365:  Point Spread:  Cardinals +9.5, Texans -9.5; Over/Under:  42.5 points

BetMGM:  Point Spread:  Cardinals +9.5, Texans -9.5; Over/Under:  42.5 points

Arizona Cardinals:  3-10 (4th place, NFC West)

Houston Texans:  8-5 (2nd place, AFC South)

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Arizona Cardinals:  lost their last game at home against the Los Angeles Rams 45-17.

Houston Texans:  won their last game on the road against the Kansas City Chiefs 20-10.

The Cardinals are entering this game with a 3-10 record overall and they have a 0-5 record in their divisional games too. They are 1-6 in their home games, 2-4 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Los Angeles Rams 45-17. Jacoby Brissett was the starting QB and he completed 25/44 passes for 271 passing yards, 2 touchdowns, and 1 interception. Jacoby Brissett led the team in rushing yards with 22. Michael Wilson led the receivers with 142 receiving yards on 11 receptions and 2 TDs. Owen Pappoe led the defense in that game with 5 solo tackles and 4 assisted tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.

 

 

 

The Texans are entering this game with an 8-5 record overall and they have a 4-1 record in their divisional games too. They are 4-2 in their home games, 4-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Kansas City Chiefs 20-10. C. J. Stroud was the starting QB and he completed 15/31 passes for 203 passing yards, 1 touchdown, and 0 interceptions. Jo'quavious Marks led the team in rushing yards with 68. Nico Collins led the receivers with 121 receiving yards on 4 receptions. Kamari Lassiter led the defense in that game with 5 solo tackles and 1 assisted tackle while Tommy Togiai led the defense in sacks with 1. Kamari Lassiter, Jalen Pitre, Azeez Al-Shaair each came away with 1 interception for them in that one.

The current betting odds have the Texans listed as a 10 point favorite in this game according to Draftkings Sportsbook. The Texans have looked really good in their games this season with their 8-5 record overall which has them right near the top of the AFC South. They have looked good on their home field too with their 4-2 home record this season. Meanwhile, the Cardinals have looked terrible in their games this season with their 3-10 record overall which has them right at the bottom of the NFC West with one of the worst records in the entire NFL. They have been a bad road team too with their 2-4 road record this year. Kyler Murray has been out for weeks now, but this entire team has been a disaster with the number of injuries they have. They are missing key players on offense and that has been a big issue for them lately. They are off a 45-17 loss to the Rams in their last one and they have been getting blown out in a ton of their games lately, their defense giving up a ton of points too. The Texans are off a 20-10 win over the Chiefs in their last one and that road win is going to give them a ton of momentum. They had a terrible start to the season, but they have turned things around with one of the best defenses in the NFL, and they look like a scary team to play now. The Cardinals have so many injuries on offense that they aren't going to be able to do much on this Texans defense, and the Texans will be able to pull away throughout this game with how bad that Cardinals defense has looked lately. The best way to place a bet here is on the Texans to cover the spread in this game. 

Cardinals Texans Prediction:  Our NFL Pick for Sunday, December 14, 2025 (1:00 pm ET start time) is Texans 24 Cardinals 10.

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Arizona Cardinals: 14-7 ATS as an underdog of 3.5 to 9.5 points. 9-4 ATS in non-conference games. 7-3 ATS after 3 or more consecutive losses. 23-14 OVER in all games where the total is between 42.5 and 49 points. 8-4 OVER after playing a division game.

Houston Texans: 7-16 ATS against NFC West division opponents. 8-21 ATS after 3 or more consecutive wins against the spread. 16-23 ATS off an upset win as a road underdog. 27-12 OVER off 3 or more consecutive unders. 25-16 OVER off an upset win as a road underdog.

Arizona Cardinals:  B. Baker (S) Injured - Thumb. D. Tomlinson (DL) Injured - Rest. K. Beachum (OG) Injured - Rest. B. Nichols (DL) Injured - Knee. J. Sweat (LB) Injured - Rest. E. Brown (OG) Injured - Personal. L. Collier (DL) Injured - Knee. J. Thompson (S) Injured - Hamstring. E. Demercado (RB) Injured - Ankle. P. Johnson Jr. (OG) Injured - Knee. M. Melton (CB) Injured - Heel. C. Jones (OG) Injured - Knee. X. Weaver (WR) Injured - Hamstring. M. Harrison Jr. (WR) Injured - Heel. D. Taylor-Demerson (S) Injured - Ankle. W. Nolen III (DL) Injured - Knee. W. Johnson (CB) Injured - Thumb.

Houston Texans:  T. Howard (OT) Injured - Personal. D. Autry (DL) Injured - Knee. S. Rankins (DL) Injured - Elbow. T. Brown (OT) Injured - Hand. N. Chubb (RB) Injured - Ribs. J. Watson (WR) Injured - Calf. A. Al-Shaair (LB) Injured - Ankle. H. Bryant (TE) Injured - Neck. E. Speed (LB) Injured - Knee. J. Hill (LB) Injured - Hamstring. K. Lassiter (CB) Injured - Foot. W. Marks (RB) Injured - Knee.

“Give credit to LA. They were better than us in every facet of the game — coaching, playing, offense, defense, special teams. That was very humbling. At one point, it's 10-10, and then you look up and you're down a lot of points quick.” - Jonathan Gannon after his team’s loss against the LA Rams in their last game. 

“It was our next game. We needed to come out and execute. Play good football. And we did.” - DeMeco Ryans after his team’s win against the Chiefs in their last game. 

WR Baccellia, Andre

WR Wilson, Michael

TE McBride, Trey

QB Brissett, Jacoby

RB Knight, Bam

WR Collins, Nico

WR Higgins, Jayden

WR Kirk, Christian

TE Schultz, Dalton

QB Stroud, C.J.

RB Marks, Woody

FB Brooks, British

Passing: Jacoby Brissett (2,459)

Rushing: Bam Knight (271)

Receiving: Trey McBride (937)

Touchdowns: Trey McBride (8)

Passing: C.J. Stroud (2,181)

Rushing: Woody Marks (554)

Receiving: Nico Collins (916)

Touchdowns: Nico Collins (5)

Coaches:

Arizona Cardinals: Jonathan Gannon (3rd season)

Houston Texans: DeMeco Ryans (3rd season)