Arizona Cardinals vs Cincinnati Bengals Prediction, Preview and Odds - 12/28/2025

Game Time: 1:00 pm ET, Sunday, December 28, 2025

Venue:  Paycor Stadium, Cincinnati, OH

Where to Watch:  FOX

DraftKings:  Point Spread:  Cardinals +7, Bengals -7; Over/Under:  53.5 points

Bet365:  Point Spread:  Cardinals +7, Bengals -7; Over/Under:  53.5 points

BetMGM:  Point Spread:  Cardinals +7, Bengals -7; Over/Under:  53.5 points

Arizona Cardinals:  3-12 (4th place, NFC West)

Cincinnati Bengals:  5-10 (3rd place, AFC North)

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Arizona Cardinals:  lost their last game at home against the Atlanta Falcons 26-19.

Cincinnati Bengals:  won their last game on the road against the Miami Dolphins 45-21.

The Cardinals are entering this game with a 3-12 record overall and they have a 0-5 record in their divisional games too. They are 1-7 in their home games, 2-5 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Atlanta Falcons 26-19. Jacoby Brissett was the starting QB and he completed 16/31 passes for 203 passing yards, 1 touchdown, and 1 interception. Michael Carter led the team in rushing yards with 65. Elijah Higgins led the receivers with 91 receiving yards on 7 receptions. Dadrion Taylor-Demerson and Akeem Davis-Gaither each led the defense in that game with 5 solo tackles and 6 assisted tackles while BJ Ojulari led the defense in sacks with 1. Denzel Burke came away with the only interception for them in that one.

 

 

 

The Bengals are entering this game with a 5-10 record overall and they have a 3-2 record in their divisional games too. They are 2-5 in their home games, 3-5 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Miami Dolphins 45-21. Joe Burrow was the starting QB and he completed 25/32 passes for 309 passing yards, 4 touchdowns, and 0 interceptions. Chase Brown led the team in rushing yards with 66 and 1 TD. Ja'Marr Chase led the receivers with 109 receiving yards on 9 receptions. Jordan Battle led the defense in that game with 4 solo tackles and 1 assisted tackle while no one on the defense recorded a sack for them. Jalen Davis and Barrett Carter each came away with 1 interception for them in that one.

The current betting odds have the Bengals listed as a 7 point favorite in this game according to Draftkings Sportsbook. The Bengals have looked terrible in their games this season with their 5-10 record overall which has them right near the bottom of the AFC North. They haven't looked good on their home field either with their 2-5 home record this season. Meanwhile, the Cardinals have looked terrible in their games this season with their 3-12 record overall which has them right at the bottom of the NFC West with one of the worst records in the entire NFL. They have been a bad road team too with their 2-5 road record this year. The Cardinals are off a 26-19 loss to the Falcons in their last one and they have been a disaster this year. The offense hasn't looked terrible with Brissett taking over, but it still hasn't been great. Their defense has also looked terrible all season and has been giving up a ton of points lately. The Bengals have been a disaster themselves, dealing with a lot of injuries and also having one of the worst defenses in the NFL, but they are off a 45-21 win over the Dolphins in their last one and they haven't given up yet despite being eliminated from playoff contention. The offense has looked a lot better with Burrow back in the lineup and this is a defense he is going to be able to torch all day. The Cardinals might have some fight late in this game, but look for the Bengals to run away with it early like most teams have been doing against the Cardinals over the last few weeks. The best way to place a bet here is on the Bengals to cover the spread in this game. 

Cardinals Bengals Prediction:  Our NFL Pick for Sunday, December 28, 2025 (1:00 pm ET start time) is Bengals 42 Cardinals 24.

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Arizona Cardinals: 4-7 ATS versus poor rushing defenses - allowing 4.5 rushing yards/carry or more. 9-14 ATS on the road after 3 or more consecutive losses against the spread. 9-5 OVER in non-conference games. 9-4 OVER when playing against a team with a losing record. 5-0 OVER vs. poor teams - outscored by 6+ points per game on the season.

Cincinnati Bengals: 10-5 ATS as a favorite of 3.5 to 9.5 points. 5-0 ATS after a win by 14 or more points. 8-4 ATS vs. bad defensive teams who give up 24 or more points/game. 10-3 OVER as a home favorite of 7 points or less. 8-4 OVER vs. bad defensive teams who give up 24 or more points/game.

Arizona Cardinals:  None.

Cincinnati Bengals:  None.

“I loved the resilience. I thought we battled in there, but ultimately fell a little short. I thought a key component of the game is that we moved it, but had to settle for some field goals. They converted some touchdowns.” - Jonathan Gannon after his team’s loss against the Falcons in their last game. 

“This is the situation we're in. This is what we can control. After the season we'll have a chance to reflect back on things that we've got to do differently.” - Zac Taylor after his team’s win against the Dolphins in their last game. 

WR Harrison Jr., Marvin

WR Wilson, Michael

WR Weaver, Xavier

TE McBride, Trey

QB Brissett, Jacoby

RB Carter, Michael

WR Chase, Ja'Marr

WR Higgins, Tee

WR Iosivas, Andrei

TE Gesicki, Mike

QB Burrow, Joe

RB Brown, Chase

Passing: Jacoby Brissett (2,911)

Rushing: Michael Carter (286)

Receiving: Trey McBride (1,098)

Touchdowns: Trey McBride (10)

Passing: Joe Flacco (1,640)

Rushing: Chase Brown (846)

Receiving: Ja'Marr Chase (1,256)

Touchdowns: Tee Higgins (10)

Coaches:

Arizona Cardinals: Jonathan Gannon (3rd season)

Cincinnati Bengals: Zac Taylor (7th season)