Arizona Cardinals vs Buffalo Bills Prediction, Preview and Odds - 09/08/2024

Game Time: 1:00 pm ET, Sunday, September 8, 2024

Venue:  Highmark Stadium, Orchard Park, NY

Where to Watch:  CBS

DraftKings:  Point Spread:  Cardinals +6, Bills -6; Over/Under:  48 points

Bet365:  Point Spread:  Cardinals +6, Bills -6; Over/Under:  48 points

BetMGM:  Point Spread:  Cardinals +6, Bills -6; Over/Under:  48.5 points

Arizona Cardinals:  0-0 (NFC West)

Buffalo Bills:  0-0 (AFC East)

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Arizona Cardinals:  N/A

Buffalo Bills:  N/A

The Cardinals finished last season with a 4-13 record overall and they were 0-6 in their division games too. They had a 2-6 record in their home games and had a 2-7 record in their road games where they will be in this game. Last season, their offense was averaging 19.4 points per game and their defense was allowing an average of 26.8 points per game. Their offense was also averaging 324.1 yards per game and their defense was allowing an average of 355.7 yards per game. Kyler Murray led the team in passing yards with 1799, James Conner led the team in rushing yards with 1040, and Trey McBride led the team in receiving yards with 825.

The Bills finished last season with an 11-6 record overall and they were 4-2 in their division games too. They had a 7-2 record in their home games and had a 4-4 record in their road games, but they will be at home in this game. Last season, their offense was averaging 26.5 points per game and their defense was allowing an average of 18.3 points per game. Their offense was also averaging 374.5 yards per game and their defense was allowing an average of 307.2 yards per game. Josh Allen led the team in passing yards with 4306, James Cook led the team in rushing yards with 1122, and Stefon Diggs led the team in receiving yards with 1183.

The current betting odds have the Bills listed as a 6 point favorite in this game according to Draftkings Sportsbook. The Bills finished last season with an 11-6 record overall and they looked great in their home games all season with their 7-2 home record. They have been a consistent playoff team over the last few years, but now they have to deal with losing Stefon Diggs. Diggs will be a hard player to replace, but the Bills were a really strong team on the ground last season too. They are getting an easier home opener too with the Cardinals coming to town. The Cards were terrible last season, going 4-13 overall, and they had a 2-7 road record too. Kyler Murray didn't play the whole season, but he wasn't really crushing teams when he came back. They are in their 2nd season with Gannon as the head coach but they still have a lot to prove in his 2nd year. This will be a tough road game for them too since they have to travel North to Buffalo, a place they don't visit often. They won't really have to deal with the cold here so they are catching a bit of a break, but they have been such a disaster as a franchise over the last few seasons. The Bills may stumble every year once they get into the playoffs, but they are still a really good regular season team and have been dominant in their home games. The best way to place a bet here is on the Bills to cover the spread in this game. 

Cardinals Bills Prediction:  Our NFL Pick for Sunday, September 8, 2024 (1:00 pm ET start time) is Bills 28 Cardinals 13.

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Arizona Cardinals: 7-13 ATS in the first half of their last 20 games. 2-8 ATS in the second quarter of their last 10 games. 12-5 to the second quarter over in their last 17 games. 

Buffalo Bills: 12-7 ATS in the second quarter of their last 19 games. 9-4 ATS in the third quarter of their last 13 games. 9-1 to the second quarter over in their last 10 games. 

Arizona Cardinals:  None.

Buffalo Bills:  None.

“We’re drastically different than this team, than that team, than the other team. Everyone has different ways to do things and I think we’re going to be fine. It’s on the coaches to do a good job of who we have to make sure we can have success.” - Jonathan Gannon on his team coming into this new NFL season.

“What I like about Bobby is our experience together and the wisdom he has, both as a secondary coach and a linebacker coach. I just feel like he’s a growth-minded individual and coach, and that’s the right approach.” - Sean McDermott on Bobby Babich calling the plays on defense this season.

WR Harrison Jr., Marvin 

WR Wilson, Michael 

WR Dortch, Greg 

TE McBride, Trey 

QB Murray, Kyler 

RB Conner, James 

WR Hollins, Mack 

WR Samuel, Curtis 

WR Shakir, Khalil 

TE Kincaid, Dalton 

QB Allen, Josh 

RB Cook, James 

FB Gilliam, Reggie

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Coaches:

Arizona Cardinals: Jonathan Gannon (2nd season)

Buffalo Bills: Sean McDermott (8th season)