American League vs National League Prediction, Preview and Odds - 07/15/2025

Game Time: 8:00 pm ET, Tuesday, July 15, 2025

Venue:  Truist Park, Atlanta, GA

Where to Watch:  FOX

DraftKings:  Moneyline odds:  American League -110, National League -110; Over/Under:  7 runs

Bet365:  Moneyline odds:  American League -110, National League -110; Over/Under:  7 runs

BetMGM:  Moneyline odds:  American League -110, National League -110; Over/Under:  7 runs

American League:  216-225 against National League opponents this season.

National League:  225-216 against American League opponents this season.

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American League:  48-44-2 against National League in All Star games.

National League:  44-48-2 against American League in All Star games.

The American League is entering this All-Star game off a win which was a bounce back for them after losing the previous year. Before that loss to the National League, the American League had won 9 All-Star games in a row so they will be looking to rebuild that run off a win last season. The American League has 2 of their players in the starting lineup, Aaron Judge and Jacob Wilson, who are the top 2 in the MLB for batting average. They also have 2 of their starters, Aaron Judge and Cal Raleigh, in the top 2 of the MLB for OPS this season. The American League has some solid pitching on their side as Garrett Crochet and Tarik Skubal are both starters with 2.23 ERA’s and Max Fried who leads the starters with 11 wins, but the National League has definitely been the much weaker league when it comes to pitching this season, so they are going to need to win this game with their lineup as that is their strength.

The National League is entering this All-Star game off a loss last year after winning the season before that. They will be looking to bounce back this year since they have lost 10 of the last 11 MLB All-Star games. The American League has dominated the National League for so many years, but they are going to have an advantage here with their pitching staff. The National League only has 1 player in the starting lineup, Will Smith, who is in the top 4 in the MLB for batting average. They do have 2 of their starting players, Shohei Ohtani and Will Smith, in the top 4 in the MLB for OPS. They also have the superior pitching staff with Paul Skenes who leads the MLB with a 2.01 ERA, and they have 3 of their pitchers in the top 6 in the MLB for ERA. The National League also has the best closer in the league, Robert Suarez, who has 28 saves this season. The National League hasn’t been the best offensively this season, but they do have some solid pitchers on the roster and will have to lean on them to win this game.

The current betting odds have the American League listed as a pick 'em in this game according to Draftkings Sportsbook. The American League is coming off a win over the National League last season, and they have been dominating the NL over the years as they have won 10 of the last 11 All-Star games. This looks to be another game where the American League has the edge too. The American League has a lot of players in their starting lineup who have been leading a lot of the offensive categories in the MLB this season. They have the ability to put up a lot more offense with the star power in that lineup and the way they have been producing this year. The National League hasn't been producing the offensive players that the AL this season so pitching is going to be very important for the NL in this one, but they have even lost their edge in that department this year. They have Skenes starting the game and he leads the MLB with the best ERA, but there are not many pitchers from the NL following him up on that list. The American League actually has a lot more pitchers with good ERA's in the top 10 of the MLB, and they have 2 of the top 3 closers in the league on their roster too. The National League has the ability to win this game as they do still have a lot of talent on their roster and it is an All-Star game where anything can happen, but the American League has the edge with both their offense and their pitching so all signs are pointing to the AL here. The best way to place a bet here is on the American League to win this game. 

American League National League Prediction:  Our MLB Pick for Tuesday, July 15, 2025 (8:00 pm ET start time) is American League 3 National League 1.

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American League: 10-1 on the moneyline in the last 11 All-Star games. 22-4-1 on the moneyline in the last 27 All-Star games. 2-1 to the under 7 runs in the last 3 All-Star games. 4-2-2 to the under 7 runs in the last 8 All-Star games. 

National League: 1-10 on the moneyline in the last 11 All-Star games. 4-22-1 on the moneyline in the last 27 All-Star games. 2-1 to the under 7 runs in the last 3 All-Star games. 4-2-2 to the under 7 runs in the last 8 All-Star games. 

American League:  INF Brandon Lowe (Rays), INF Alex Bregman (Red Sox), INF Jeremy Peña (Astros), INF José Ramírez (Guardians), OF Julio Rodríguez (Mariners), Garrett Crochet (Red Sox), Yusei Kikuchi (Angels), Max Fried (Yankees), Jacob deGrom (Rangers), Hunter Brown (Astros).

National League:  Chris Sale (Braves), Zack Wheeler (Phillies),  Robbie Ray (Giants), Freddy Peralta (Brewers),  Yoshinobu Yamamoto (Dodgers), Matthew Boyd (Cubs).

"Excited to go oat it with these guys tomorrow night, and obviously be able to give the ball to Tarik Skubal. Coming off a Cy Young season, and continuing that dominance in the first half of the season. Can't wait to see him go get us off to a good start tomorrow." - Aaron Boone on managing the AL in the MLB All-Star game.

"It's such a huge honor to be on the stage and play with all these unbelievable players, some of them that I've watched for years." - Paul Skenes on starting the MLB All-Star game.

C: Cal Raleigh (SEA)

1B: Vladimir Guerrero Jr. (TOR)

2B: Gleyber Torres (DET)

3B: Junior Caminero (TB) 

SS: Jacob Wilson (ATH)

OF: Aaron Judge (NYY)

OF: Riley Greene (DET)

OF: Javier Báez (DET)

DH: Ryan O'Hearn (BAL)

SP: Tarik Skubal (DET)

C: Will Smith (LAD)

1B: Freddie Freeman (LAD)

2B: Ketel Marte (AZ)

3B: Manny Machado (SD)

SS: Francisco Lindor (NYM)

OF: Ronald Acuña Jr. (ATL)

OF: Pete Crow-Armstrong (CHC)

OF: Kyle Tucker (CHC)

DH: Shohei Ohtani (LAD)

SP: Paul Skenes (PIT)

C: Alejandro Kirk (TOR)

INF: Jonathan Aranda (TB)

INF: Alex Bregman (BOS)

INF: Jazz Chisholm Jr. (NYY)

INF: Maikel Garcia (KC) 

INF: Brandon Lowe (TB)

INF: Zach McKinstry (DET) 

INF: Isaac Paredes (HOU) 

INF: Jeremy Peña (HOU)

INF: Bobby Witt Jr. (KC)

OF: Randy Arozarena (SEA) 

OF: Byron Buxton (MIN)

OF: Steven Kwan (CLE)

OF: Julio Rodríguez (SEA)

DH: Brent Rooker (ATH)

C: Hunter Goodman (COL)

INF: Pete Alonso (NYM)

INF: Elly De La Cruz (CIN)

INF: Brendan Donovan (STL)

INF: Matt Olson (ATL)

INF: Eugenio Suárez (AZ)

OF: Corbin Carroll (AZ)

OF: Kyle Stowers (MIA)

OF: Fernando Tatis Jr. (SD)

OF: James Wood (WSH)

DH: Kyle Schwarber (PHI)

RHP: Hunter Brown (HOU)

LHP: Kris Bubic (KC)

LHP: Garrett Crochet (BOS)

RHP: Jacob deGrom (TEX)

LHP: Max Fried (NYY)

LHP: Yusei Kikuchi (LAA)

RHP: Casey Mize (DET) 

RHP: Drew Rasmussen (TB) 

LHP: Carlos Rodón (NYY) 

RHP: Joe Ryan (MIN) 

RHP: Shane Smith (CWS)

RHP: Bryan Woo (SEA)

LHP: Andrew Abbott (CIN) 

LHP: Matthew Boyd (CHC)

LHP: MacKenzie Gore (WSH)

LHP: Clayton Kershaw (LAD) -- Legend Pick

RHP: Jacob Misiorowski (MIL) 

RHP: Freddy Peralta (MIL)

LHP: David Peterson (NYM) 

LHP: Robbie Ray (SF)

LHP: Chris Sale (ATL)

RHP: Logan Webb (SF)

RHP: Zack Wheeler (PHI)

RHP: Yoshinobu Yamamoto (LAD)

LHP: Aroldis Chapman (BOS)

RHP: Carlos Estévez (KC) 

LHP: Josh Hader (HOU)

RHP: Andrés Muñoz (SEA)

RHP: Jason Adam (SD)

RHP: Edwin Díaz (NYM)

RHP: Trevor Megill (MIL) 

RHP: Randy Rodríguez (SF)

RHP: Robert Suarez (SD) 

LHP: Adrian Morejon (SD) 

Batting Average:  Aaron Judge (.355)

Hits:  Aaron Judge (125)

Home Runs:  Cal Raleigh (38)

RBI:  Cal Raleigh (82)

Stolen Bases:  José Caballero (31)

Wins:  Max Fried (11)

Saves:  Josh Hader (25)

ERA:  Garrett Crochet (2.23)

Batting Average:  Will Smith (.323)

Hits:  Manny Machado (107)

Home Runs:  Shohei Ohtani (32)

RBI:  Eugenio Suárez (78)

Stolen Bases:  Pete Crow-Armstrong (22)

Wins:  Freddy Peralta (11)

Saves:  Robert Suarez (28)

ERA:  Paul Skenes (2.01)

Managers:

American League: Aaron Boone (New York Yankees)

National League: Dave Roberts (Los Angeles Dodgers)